IUPAC name
3D model (JSmol)
Molar mass 286.45 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)
Infobox references

Ferruginol is a natural phenol and a meroterpene (a chemical compound containing a terpenoid substructure) that has been isolated from the needles of the redwood Sequoia sempervirens. The terpenoid part is a diterpene of the abietane chemical class.

Research published in 2005 found that this and other compound of the class from Sequoia have anti-tumor properties, and showed in vitro human colon, breast, and lung tumor reduction and reduction in oncogene transformed cells as well. Specific activity of tumor growth inhibition (GI) is 2-5 micrograms/milliliter.[1]

Ferruginol has also been found to have antibacterial activity.[2][3] Gastroprotective effects of ferruginol have also been noted.[4]


  1. ^ Son, Kh; Oh, Hm; Choi, Sk; Han, Dc; Kwon, Bm (Apr 2005). "Anti-tumor abietane diterpenes from the cones of Sequoia sempervirens". Bioorganic & Medicinal Chemistry Letters. 15 (8): 2019–21. doi:10.1016/j.bmcl.2005.02.057. PMID 15808460.
  2. ^ E.C.J. Smith; G.W. Kaatz; E.M. Williamson; S. Gibbons. "P-168: The Resistance Modifying Activity of Ferruginol" (PDF). Archived from the original (PDF) on October 9, 2007. Cite journal requires |journal= (help)
  3. ^ C. Flores; J. Alarcón; J. Becerra; M. Bittner; M. Hoeneisen; M. Silva (2001). "EXTRACTABLE COMPOUNDS OF NATIVE TREES: CHEMICAL AND BIOLOGICAL STUDY I: Bark of Prumnopytis andina (Podocarpaceae) and Austrocedrus chilensis (Cupressaceae)". Bol. Soc. Chil. Quím. 46 (1). doi:10.4067/S0366-16442001000100010.
  4. ^ Areche, Carlos; Theoduloz, Cristina; Yáñez, Tania; Souza-Brito, Alba R. M.; Barbastefano, VíCtor; De Paula, DéBora; Ferreira, Anderson L.; Schmeda-Hirschmann, Guillermo; Rodríguez, Jaime A. (2008). "Gastroprotective activity of ferruginol in mice and rats: effects on gastric secretion, endogenous prostaglandins and non-protein sulfhydryls". Journal of Pharmacy and Pharmacology. 60 (2): 245–51. doi:10.1211/jpp.60.2.0014. PMID 18237473.