Gutta-percha refers both to trees of the genus Palaquium in the family Sapotaceae and the rigid, naturally biologically inert, resilient, electrically nonconductive, thermoplastic latex produced from the sap of these trees, particularly from Palaquium gutta. It is a polymer of isoprene which forms a rubber-like elastomer.
Palaquium gutta trees are 5–30 m tall and up to 1 m in trunk diameter. The leaves are evergreen, alternate or spirally arranged, simple, entire, 8–25 cm long, glossy green above, and often yellow or glaucous below. The flowers are produced in small clusters along the stems, each flower with a white corolla with four to seven (mostly six) acute lobes. The fruit is an ovoid 3–7 cm berry, containing one to four seeds; in many species, the fruit is edible.
Chemically, gutta-percha is a polyterpene, a polymer of isoprene, or polyisoprene, specifically (trans-1,4-polyisoprene). The cis structure of polyisoprene is the common latex elastomer. While latex rubbers are amorphous in molecular structure, gutta-percha (the trans structure) crystallizes, leading to a more rigid material.
During the second half of the 19th century, gutta-percha was used for many domestic and industrial purposes, and it became a household word. In particular, it was needed as insulation for underwater telegraph cables, which, according to author John Tully, led to unsustainable harvesting and collapse of supply.
According to Harvey Wickes Felter and John Uri Lloyd's Endodontology:
Even long before Gutta-percha was introduced into the Western world, it was used in a less processed form by the natives of the Malaysian archipelago for making knife handles, walking sticks and other purposes. The first European to discover this material was John Tradescant, who collected it in the far east in 1656. He named this material "Mazer wood". Dr. William Montgomerie, a medical officer in Indian service, introduced gutta-percha into practical use in the West. He was the first to appreciate the potential of this material in medicine, and he was awarded the gold medal by the Royal Society of Arts, London in 1843.
Western inventors discovered the properties of gutta-percha latex in 1842 through samples sent to England by William Montgomerie, although the people of its Malayan habitat had used it for many applications for centuries. Allowing this fluid to evaporate and coagulate in the sun produced a latex which could be made flexible again with hot water, but which did not become brittle, unlike rubber prior to the discovery of vulcanization.
By 1845, telegraph wires insulated with gutta-percha were being manufactured in the UK. It served as the insulating material for early undersea telegraph cables, including the first transatlantic telegraph cable. The material was a major constituent of Chatterton's compound used as an insulating sealant for telegraph and other electrical cables.
The dielectric constant of dried gutta-percha ranges from 2.56 to 3.01. Resistivity of dried gutta-percha ranges from 25 x 1014 to 370 x 1014 ohm-cm. 
In the mid-19th century, gutta-percha was used to make furniture, notably by the Gutta Percha Company, established in 1847. Several of these ornate, revival-style pieces were shown at the 1851 Great Exhibition in Hyde Park, London. The company also made a range of utensils.
The "guttie" golf ball (which had a solid gutta-percha core) revolutionized the game. Gutta-percha was used to make "mourning" jewelry, because it was dark in color and could be easily molded into beads or other shapes. Pistol hand grips and rifle shoulder pads were also made from gutta-percha, since it was hard and durable, though it fell into disuse when synthetic plastics such as Bakelite became available.
The same bioinertness that made it suitable for marine cables also means it does not readily react within the human body. It is used in a variety of surgical devices and during root canal therapy. It is the predominant material used to obturate, or fill, the empty space inside the root of a tooth after it has undergone endodontic therapy. Its physical and chemical properties, including but not limited to its inertness and biocompatibility, melting point, ductility, and malleability, make it important in endodontics, e.g., as gutta-percha points. Zinc oxide is added to reduce brittleness and improve plasticity. Barium sulfate is added to provide radiopacity so that its presence and location can be verified in dental X-ray images.
Gutta-percha remained an industrial staple well into the 20th century, when it was gradually replaced with superior synthetic materials such as Bakelite, though a similar and cheaper natural material called balatá was often used in gutta-percha's place. The two materials are almost identical, and balatá is often called gutta-balatá.
Blocks of flotsam, about the size of a chopping-board, bearing the name "Tjipetir" (a plantation in the Dutch East Indies—now Indonesia—operating in the late 19th and early 20th centuries), were washed up on the beaches of northern Europe for some time through 2013 and 2014. They are believed to be blocks of gutta-percha from the Japanese liner Miyazaki Maru, which was sunk 150 miles (240 km) west of the Isles of Scilly in 1917.
- Bill Burns, The Gutta Percha Company, atlantic-cable.com, accessed 6 October 2010.
- Tully, John (2011). The Devil's Milk. NYU Press.
- Tully, John (2009). "A Victorian Ecological Disaster: Imperialism, the Telegraph, and Gutta-Percha". Journal of World History. 20 (4): 559–579. doi:10.1353/jwh.0.0088. muse.jhu.edu
- Harvey Wickes Felter and John Uri Lloyd. "Gutta-Percha-: An Untold Story. Prakesh et al. ~2001 Endodontology". King's American Dispensatory http://www.ibiblio.org/herbmed/eclectic/kings isonandra.html[dead link]
- Schlesinger, Henry (2010). The battery how portable power sparked a technological revolution. New York: HarperCollins e-books. ISBN 9780061985294.
- Curtis, H.L. Dielectric Constant, Power Factor and Resistivity of Rubber and Gutta_Percha (PDF) (Report). United States N.I.S.T.
- Green, Michael S. (2010). Politics and America in Crisis: The Coming of the Civil War. Santa Barbara, CA: ABC-CLIO. p. 94. ISBN 978-0-313-08174-3 – via Google Books.
- Yee, Fulton S.; Marlin, Jay; Krakow, Alvin Arlen; Gron, Poul (1977). "Three-dimensional obturation of the root canal using injection-molded, thermoplasticized dental gutta-percha". Journal of Endodontics. 3 (5): 168–174. doi:10.1016/s0099-2399(77)80091-5.
- "Tjipetir mystery: Why are rubber-like blocks washing up on European beaches?". www.bbc.co.uk. BBC. Retrieved 1 December 2014.
- Germplasm Resources Information Network: Palaquium
- Gutta-percha on the Transatlantic cable site
- The Gutta Percha Company on the History of the Atlantic Cable site
- "The New Philippine Currency". Annual Reports of the War Department for the Fiscal Year Ended June 30, 1903 - Report of the Philippine Commission. VI. Washington, D.C.: U.S. Government Printing Office. 1904. pp. 388–411. OCLC 220674586.