Acetoacetyl coenzyme A.svg
3D model (JSmol)
ECHA InfoCard 100.014.378
MeSH acetoacetyl+CoA
Molar mass 851.609 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Acetoacetyl CoA is the precursor of HMG-CoA in the mevalonate pathway, which is essential for cholesterol biosynthesis. It also takes a similar role in the ketone bodies synthesis (ketogenesis) pathway of the liver. In the ketone bodies digestion pathway (in the tissue), it is no longer associated with having HMG-CoA as a product or as a reactant.

It is created from acetyl-CoA, a thioester, which reacts with the enolate of a second molecule of acetyl-CoA in a Claisen condensation reaction,[1] and it is acted upon by HMG-CoA synthase to form HMG-CoA. During the metabolism of leucine, this last reaction is reversed.

Mevalonate pathway


  1. ^ Yurkanis, Bruice, Paula (2017). Organic chemistry. Pearson. ISBN 9780134042282. OCLC 974910578.

See also[edit]