Cannabis Ruderalis

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    JWH-184
    JWH-184.png
    Legal status
    Legal status
    Identifiers
    • 3-[(4-Methyl-1-naphthalenyl)methyl]-1-pentyl-1H-indole
    CAS Number
    ChemSpider
    UNII
    Chemical and physical data
    FormulaC25H27N
    Molar mass341.498 g·mol−1
    3D model (JSmol)
    • CCCCCn1cc(c2c1cccc2)Cc3ccc(c4c3cccc4)C
    • InChI=1S/C25H27N/c1-3-4-9-16-26-18-21(24-12-7-8-13-25(24)26)17-20-15-14-19(2)22-10-5-6-11-23(20)22/h5-8,10-15,18H,3-4,9,16-17H2,1-2H3
    • Key:FSOLXFPDIJJWBM-UHFFFAOYSA-N

    JWH-184 is a synthetic cannabinoid receptor ligand from the naphthylmethylindole family. It is the carbonyl-reduced derivative of related compound JWH-122. The binding affinity of JWH-184 for the CB1 receptor is reported as Ki = 23 ± 6 nM.[1]

    In the United States, all CB1 receptor agonists of the 3-(1-naphthylmethane)indole class such as JWH-184 are Schedule I Controlled Substances.[2]

    See also[edit]

    References[edit]

    1. ^ Huffman JW, Mabon R, Wu MJ, Lu J, Hart R, Hurst DP, et al. (February 2003). "3-Indolyl-1-naphthylmethanes: new cannabimimetic indoles provide evidence for aromatic stacking interactions with the CB(1) cannabinoid receptor". Bioorganic & Medicinal Chemistry. 11 (4): 539–49. doi:10.1016/s0968-0896(02)00451-0. PMID 12538019. S2CID 29107765.
    2. ^ 21 U.S.C. § 812: Schedules of controlled substances
    source: https://en.wikipedia.org/wiki/JWH-184

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