|CompTox Dashboard (EPA)|
|Chemical and physical data|
|Molar mass||342.523 g·mol−1|
|3D model (JSmol)|
Tetrahydrocannabiphorol (THCP) is a potent phytocannabinoid, a CB1 and CB2 agonist which was known as a synthetic homologue of THC, but for the first time in 2019 was isolated as a natural product in trace amounts from Cannabis sativa. It is structurally similar to Δ9-THC, the main active component of cannabis, but with the pentyl side chain extended to heptyl. Since it has a longer side chain, its cannabinoid effects are "far higher than Δ9-THC itself." Tetrahydrocannabiphorol has a reported binding affinity of 1.2nM at CB1, approximately 33 times that of Delta-9-THC (40nM at CB1).
The Δ8 isomer is also known as a synthetic cannabinoid under the code name JWH-091. It's unconfirmed whether or not Delta-8-THCP is found naturally in cannabis plants, but likely is due to Delta-8-THC itself being a degraded form of Delta-9-THC.  JWH-091 has approximately double the binding affinity at the CB1 receptor (22nM ± 3.9nM) in comparison to Delta-9-THC (40.7nM ± 1.7nM) or Delta-8-THC (44nM ± 12nM), but appears significantly lower in vitro than the binding activity of Delta-9-THCP (Ki = 1.2 nM CB1)
Natural occurrence in Cannabis
Delta-9-THCP occurs naturally in Cannabis but in small amounts, an analysis on mid to high THC strains ranged approximately from 0.0023% to 0.0136% (w/w) (approximately 0.02mg-0.13mg per gram) with no correlation with THC percentage, such a strain with 8% THC vs 20% THC both with similar amounts of THCP.
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