Available structures
PDBOrtholog search: PDBe RCSB
AliasesS1PR2, AGR16, EDG-5, EDG5, Gpcr13, H218, LPB2, S1P2, DFNB68, sphingosine-1-phosphate receptor 2
External IDsOMIM: 605111 MGI: 99569 HomoloGene: 3118 GeneCards: S1PR2
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for S1PR2
Genomic location for S1PR2
Band19p13.2Start10,221,433 bp[1]
End10,231,331 bp[1]
RNA expression pattern
PBB GE EDG5 208537 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 19: 10.22 – 10.23 MbChr 9: 20.96 – 20.98 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Sphingosine-1-phosphate receptor 2 also known as S1PR2 or S1P2 is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P).[5]


This protein participates in sphingosine 1-phosphate-induced cell proliferation, survival, and transcriptional activation.[5] It has also been shown to interact with Nogo-A (RTN4), an neurite outgrowth inhibitor. [6] S1PR2 is expressed on neuronal and vascular cells and is crucial for the migration and growth of developing and injured neuronal and vascular system [7] [8]

See also[edit]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000267534 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000043895 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: S1PR2, sphingosine-1-phosphate receptor 2".
  6. ^ Kempf A, Tews B, Arzt ME, Weinmann O, Obermair FJ, Pernet V, Zagrebelsky M, Delekate A, Iobbi C, Zemmar A, Ristic Z, Gullo M, Spies P, Dodd D, Gygax D, Korte M, Schwab ME, Schiavo G (14 January 2014). "The Sphingolipid Receptor S1PR2 Is a Receptor for Nogo-A Repressing Synaptic Plasticity". PLOS Biology. 12 (1): e1001763. doi:10.1371/journal.pbio.1001763. PMC 3891622. PMID 24453941.
  7. ^ Rust R, Grönnert L, Gantner C, Enzler A, Mulders G, Weber RZ, Siewert A, Limasale YDP, Meinhardt A, Maurer MA, Sartori AM, Hofer AS, Werner C, Schwab ME (9 July 2019). "Nogo-A targeted therapy promotes vascular repair and functional recovery following stroke". Proceedings of the National Academy of Sciences. 116 (28): 14270–14279. doi:10.1073/pnas.1905309116. PMC 6628809. PMID 31235580.
  8. ^ Rust R, Grönnert L, Weber RZ, Mulders G, Schwab ME (September 2019). "Refueling the Ischemic CNS: Guidance Molecules for Vascular Repair". Trends in Neurosciences. 42 (9): 644–656. doi:10.1016/j.tins.2019.05.006. PMID 31285047.

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.