Prokineticin receptor 2

PROKR2
Identifiers
Aliases PROKR2, GPR73L1, GPR73b, GPRg2, HH3, KAL3, PKR2, dJ680N4.3, prokineticin receptor 2
External IDs MGI: 2181363 HomoloGene: 16368 GeneCards: PROKR2
Gene location (Human)
Chromosome 20 (human)
Chr. Chromosome 20 (human)[1]
Chromosome 20 (human)

Genomic location for PROKR2
Genomic location for PROKR2
Band 20p12.3 Start 5,302,040 bp[1]
End 5,314,369 bp[1]
RNA expression pattern
PBB GE PROKR2 gnf1h10315 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_144773

NM_144944

RefSeq (protein)

NP_658986

NP_659193

Location (UCSC) Chr 20: 5.3 – 5.31 Mb Chr 2: 132.34 – 132.39 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Prokineticin receptor 2 (PKR2), is a G protein-coupled receptor encoded by the PROKR2 gene in humans.[5]

Function[edit]

Prokineticins are secreted proteins that can promote angiogenesis and induce strong gastrointestinal smooth muscle contraction. The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor for prokineticins. The encoded protein is similar in sequence to GPR73, another G protein-coupled receptor for prokineticins.[5]

Mutations in the PROKR2 (also known as KAL3) gene have been implicated in hypogonadotropic hypogonadism and gynecomastia.[6]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000101292Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000050558Ensembl, May 2017
  3. ^ “Human PubMed Reference:”.
  4. ^ “Mouse PubMed Reference:”.
  5. ^ a b “Entrez Gene: PROKR2 prokineticin receptor 2”.
  6. ^ Narula HS, Carlson HE (November 2014). “Gynaecomastia–pathophysiology, diagnosis and treatment”. Nature Reviews. Endocrinology. 10 (11): 684–98. doi:10.1038/nrendo.2014.139. PMID 25112235.

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.