Neuropeptide Y receptor Y1

NPY1R
Protein NPY1R PDB 2F1U.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNPY1R, NPY1-R, NPYR, Neuropeptide Y receptor Y1
External IDsOMIM: 162641 MGI: 104963 HomoloGene: 700 GeneCards: NPY1R
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for NPY1R
Genomic location for NPY1R
Band4q32.2Start163,323,962 bp[1]
End163,344,832 bp[1]
RNA expression pattern
PBB GE NPY1R 205440 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000909

NM_010934
NM_001358955

RefSeq (protein)

NP_000900

NP_035064
NP_001345884

Location (UCSC)Chr 4: 163.32 – 163.34 MbChr 8: 66.7 – 66.71 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Neuropeptide Y receptor type 1 is a protein that in humans is encoded by the NPY1R gene.[5][6]

Selective ligands[edit]

Agonists[edit]

Antagonists[edit]

Peptide
  • BVD-10 (selective NPY1 antagonist, CAS# 262418-00-8)
  • GR-231,118 (mixed NPY1 antagonist / NPY4 agonist, CAS# 158859-98-4)
Non-peptide
  • BIBO-3304 (CAS# 191868-14-1)
  • BIBP-3226 (CAS# 159013-54-4)
  • PD-160,170 (CAS# 181468-88-2)

Available Structures[edit]

  • 5ZBH (Neuropeptide Y1 bound to antagonist BMS-193835)[7]
  • 5ZBQ (Neuropeptide Y1 bound to antagonist UR-MK299)[7]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164128 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036437 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Herzog H, Baumgartner M, Vivero C, Selbie LA, Auer B, Shine J (March 1993). "Genomic organization, localization, and allelic differences in the gene for the human neuropeptide Y Y1 receptor". The Journal of Biological Chemistry. 268 (9): 6703–7. PMID 8095935.
  6. ^ "Entrez Gene: NPY1R neuropeptide Y receptor Y1".
  7. ^ a b Yang Z, Han S, Keller M, Kaiser A, Bender BJ, Bosse M, Burkert K, Kögler LM, Wifling D, Bernhardt G, Plank N, Littmann T, Schmidt P, Yi C, Li B, Ye S, Zhang R, Xu B, Larhammar D, Stevens RC, Huster D, Meiler J, Zhao Q, Beck-Sickinger AG, Buschauer A, Wu B (April 2018). "1 receptor". Nature. 556 (7702): 520–524. doi:10.1038/s41586-018-0046-x. PMC 5920736. PMID 29670288.

Further reading[edit]

External links[edit]