AliasesGPR37, EDNRBL, PAELR, hET(B)R-LP, G protein-coupled receptor 37
External IDsOMIM: 602583 MGI: 1313297 HomoloGene: 3875 GeneCards: GPR37
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for GPR37
Genomic location for GPR37
Band7q31.33Start124,743,885 bp[1]
End124,765,792 bp[1]
RNA expression pattern
PBB GE GPR37 214586 at fs.png

PBB GE GPR37 209631 s at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 7: 124.74 – 124.77 Mbn/a
PubMed search[2][3]
View/Edit HumanView/Edit Mouse

Probable G-protein coupled receptor 37 is a protein that in humans is encoded by the GPR37 gene.[4][5]


GPR37 has been shown to interact with HSPA1A[6] and Parkin (ligase).[6][7] GPR37 is a receptor for prosaposin. It was previously thought to be a receptor for head activator, a neuropeptide found in the hydra, but early reports of head activator in mammals were never confirmed.[8]

GPR37 signaling has been shown to modulate the migration of olfactory ensheathing cells (OECs) and gonadotropin-releasing hormone (GnRH) cells in mice.[9]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000170775 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Marazziti D, Golini E, Gallo A, Lombardi MS, Matteoni R, Tocchini-Valentini GP (November 1997). "Cloning of GPR37, a gene located on chromosome 7 encoding a putative G-protein-coupled peptide receptor, from a human frontal brain EST library". Genomics. 45 (1): 68–77. doi:10.1006/geno.1997.4900. PMID 9339362.
  5. ^ "Entrez Gene: GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)".
  6. ^ a b Imai Y, Soda M, Hatakeyama S, Akagi T, Hashikawa T, Nakayama KI, Takahashi R (July 2002). "CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity". Molecular Cell. 10 (1): 55–67. doi:10.1016/S1097-2765(02)00583-X. PMID 12150907.
  7. ^ Imai Y, Soda M, Inoue H, Hattori N, Mizuno Y, Takahashi R (June 2001). "An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin". Cell. 105 (7): 891–902. doi:10.1016/S0092-8674(01)00407-X. PMID 11439185.
  8. ^ Meyer, Rebecca C.; Giddens, Michelle M.; Schaefer, Stacy A.; Hall, Randy A. (4 June 2013). "GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin". Proceedings of the National Academy of Sciences. 110 (23): 9529–34. Bibcode:2013PNAS..110.9529M. doi:10.1073/pnas.1219004110. PMC 3677493. PMID 23690594.
  9. ^ Saadi H, Shan Y, Wray S (2019). "GPR37 Signaling Modulates Migration of Olfactory Ensheathing Cells and Gonadotropin Releasing Hormone Cells in Mice". Frontiers in Cellular Neuroscience. 13: 200. doi:10.3389/fncel.2019.00200. PMC 6521704. PMID 31143101.

Further reading[edit]