AliasesFFAR4, BMIQ10, GPR120, GPR129, GT01, O3FAR1, PGR4, free fatty acid receptor 4
External IDsOMIM: 609044 MGI: 2147577 HomoloGene: 18769 GeneCards: FFAR4
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for FFAR4
Genomic location for FFAR4
Band10q23.33Start93,566,665 bp[1]
End93,604,480 bp[1]
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 10: 93.57 – 93.6 MbChr 19: 38.1 – 38.11 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

G-protein coupled receptor 120 is a protein that in humans is encoded by the GPR120 gene.[5][6]

GPR120 is a member of the rhodopsin family of G protein-coupled receptors (GPRs).[5][6]

GPR120 has also been shown to mediate the anti-inflammatory and insulin-sensitizing effects of omega 3 fatty acids.[7] Lack of GPR120 is responsible for reduced fat metabolism, thereby leading to obesity.[8]

Additionally, GPR120 has been implicated to be involved in the ability to taste fats.[9] It is expressed in taste bud cells (specifically cell type II, which contain other G-protein coupled taste receptors), and its absence leads to reduced preference to two types of fatty acid (linoleic acid and oleic acid), as well as decreased neuronal response to oral fatty acids.[10]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000186188 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000054200 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB (Nov 2003). "Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives". FEBS Lett. 554 (3): 381–8. doi:10.1016/S0014-5793(03)01196-7. PMID 14623098.
  6. ^ a b "Entrez Gene: GPR120 G protein-coupled receptor 120".
  7. ^ Oh DY, Talukdar S, Bae EJ, Imamura T, Morinaga H, Fan W, Li P, Lu WJ, Watkins SM, Olefsky JM (2010). "GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects". Cell. 142 (5): 687–698. doi:10.1016/j.cell.2010.07.041. PMC 2956412. PMID 20813258.
  8. ^ Ichimura A, Hirasawa A, Poulain-Godefroy O, Bonnefond A, Hara T, Yengo L, et al. (2012). "Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human" (PDF). Nature. 483 (7389): 350–4. doi:10.1038/nature10798. hdl:2433/153278. PMID 22343897.
  9. ^ Dipatrizio, N. V. (2014). "Is fat taste ready for primetime?". Physiology & Behavior. 136: 145–54. doi:10.1016/j.physbeh.2014.03.002. PMC 4162865. PMID 24631296.
  10. ^ PMID 20573884

Further reading[edit]