Clinical data
ATC code
  • none
CAS Number
PubChem CID
CompTox Dashboard (EPA)
Chemical and physical data
Formula C19H18ClFN2O3S
Molar mass 408.87 g·mol−1
3D model (JSmol)

Elfazepam[1] is a drug which is a benzodiazepine derivative.[2] Presumably it has sedative and anxiolytic actions like those of other benzodiazepines.

Orexigenic properties in animals.[3][4] The mechanism for increasing feed intake is not clear and has been subject of investigation.[5] It has been found that elfazepam suppresses gastric acid secretion.[6]


Elfazepam synthesis: U.S. Patent 4,010,154

Benzophenone derivative 1 is reacted with a glycine equivalent masked as an oxazolidine-2,5-dione 2 to give the final product 3 Elfazepam.


  1. ^ U.S. Patent 4,010,154
  2. ^ Psychotropics.dk
  3. ^ Baile, CA.; McLaughlin, CL. (Nov 1979). “A review of the behavioral and physiological responses to elfazepam, a chemical feed intake stimulant”. J Anim Sci. 49 (5): 1371–95. PMID 396294.
  4. ^ Baile, CA.; Naylor, J.; McLaughlin, CL.; Catanzaro, CA. (Aug 1981). “Endotoxin-elicited fever and anorexia and elfazepam-stimulated feeding in sheep”. Physiol Behav. 27 (2): 271–7. doi:10.1016/0031-9384(81)90269-9. PMID 7029576.
  5. ^ Keim, DA.; Baile, CA.; Bolton, JR.; Wangsness, PJ.; Della Fera, MA. (Jan 1979). “Abomasal function following injections of elfazepam and 9-aza-cannabinol”. Pharmacol Biochem Behav. 10 (1): 63–70. doi:10.1016/0091-3057(79)90170-9. PMID 35793.
  6. ^ Van Den Broek, GW.; Robertson, J.; Keim, DA.; Baile, CA. (Jul 1979). “Feeding and depression of abomasal secretion in sheep elicited by elfazepam and 9-aza-cannabinol”. Pharmacol Biochem Behav. 11 (1): 51–6. doi:10.1016/0091-3057(79)90296-x. PMID 493298.