bombesin receptor subtype 3 also known as BRS-3 or BB 3 is a  protein which in humans is encoded by the BRS3 gene. 
Function [ edit ]
bombesin-like peptides are widely distributed in the central nervous system as well as in the gastrointestinal tract, where they modulate smooth-muscle contraction, exocrine and endocrine processes, metabolism, and behavior. They bind to G protein-coupled receptors on the cell surface to elicit their effects. Bombesin-like peptide receptors include gastrin-releasing peptide receptor, neuromedin B receptor, and bombesin-like receptor-3 (BRS3; this article). 
3 is a G protein-coupled receptor. BB  3 only interacts with known naturally occurring bombesin-related peptides with low affinity and therefore, as it has no natural high-affinity ligand, is classified as an orphan receptor.  
References [ edit ]
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GRCh38: Ensembl release 89: ENSG00000102239 - Ensembl, May 2017
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GRCm38: Ensembl release 89: ENSMUSG00000031130 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Bombesin Receptors: BB. 3" IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
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Fathi Z, Corjay MH, Shapira H, Wada E, Benya R, Jensen R, Viallet J, Sausville EA, Battey JF (March 1993). "BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells". J. Biol. Chem. 268 (8): 5979–84. PMID 8383682.
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Ohki-Hamazaki H, Wada E, Matsui K, Wada K (July 1997). "Cloning and expression of the neuromedin B receptor and the third subtype of bombesin receptor genes in the mouse". Brain Res. 762 (1–2): 165–72. doi: 10.1016/S0006-8993(97)00380-6. PMID 9262170.
"Entrez Gene: BRS3 bombesin-like receptor 3".
Mantey SA, Weber HC, Sainz E, Akeson M, Ryan RR, Pradhan TK, Searles RP, Spindel ER, Battey JF, Coy DH, Jensen RT (1997). "Discovery of a high affinity radioligand for the human orphan receptor, bombesin receptor subtype 3, which demonstrates that it has a uniquepharmacology compared with other mammalian bombesin receptors". J. Biol. Chem. 272 (41): 26062–26071. doi: 10.1074/jbc.272.41.26062. PMID 9325344.
Jensen RT, Battey JF, Spindel ER, Benya RV (2007). "International Union of Pharmacology: The Bombesin Receptors. Nomenclature, distribution, pharmacology, signaling and functions in normal and diseased states". Pharmacol. Rev. 60 (1): 1–42. doi: 10.1124/pr.107.07108. PMC . 2517428 PMID 18055507.
Further reading [ edit ]
Gorbulev V, Akhundova A, Grzeschik KH, Fahrenholz F (1994). "Organization and chromosomal localization of the gene for the human bombesin receptor subtype expressed in pregnant uterus" (PDF). FEBS Lett. 340 (3): 260–4. doi: 10.1016/0014-5793(94)80150-9. PMID 8131855.
Fathi Z, Corjay MH, Shapira H, et al. (1993). "BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells". J. Biol. Chem. 268 (8): 5979–84. PMID 8383682.
Kane MA, Toi-Scott M, Johnson GL, et al. (1996). "Bombesin-like peptide receptors in human bronchial epithelial cells". Peptides. 17 (1): 111–8. doi: 10.1016/0196-9781(95)02088-8. PMID 8822519.
Ohki-Hamazaki H, Watase K, Yamamoto K, et al. (1997). "Mice lacking bombesin receptor subtype-3 develop metabolic defects and obesity". Nature. 390 (6656): 165–9. doi: 10.1038/36568. PMID 9367152.
Ryan RR, Weber HC, Hou W, et al. (1998). "Ability of various bombesin receptor agonists and antagonists to alter intracellular signaling of the human orphan receptor BRS-3". J. Biol. Chem. 273 (22): 13613–24. doi: 10.1074/jbc.273.22.13613. PMID 9593699.
Liu J, Lao ZJ, Zhang J, et al. (2002). "Molecular basis of the pharmacological difference between rat and human bombesin receptor subtype-3 (BRS-3)". Biochemistry. 41 (28): 8954–60. doi: 10.1021/bi0202777. PMID 12102638.
Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. doi: 10.1038/nature03440. PMC . 2665286 PMID 15772651.
Hou X, Wei L, Harada A, Tatamoto K (2007). "Activation of bombesin receptor subtype-3 stimulates adhesion of lung cancer cells". Lung Cancer. 54 (2): 143–8. doi: 10.1016/j.lungcan.2006.08.005. PMID 16979789. Tan YR, Qin XQ, Xiang Y, et al. (2007). "PPARalpha and AP-2alpha regulate bombesin receptor subtype 3 expression in ozone-stressed bronchial epithelial cells". Biochem. J. 405 (1): 131–7. doi: 10.1042/BJ20061754. PMC . 1925247 PMID 17355223.
External links [ edit ] This article incorporates text from the
United States National Library of Medicine, which is in the public domain.