|Illustration from Köhler's Medicinal Plants 1887|
Atropa belladonna, commonly known as belladonna or deadly nightshade, is a poisonous perennial herbaceous plant in the nightshade family Solanaceae, which includes tomatoes, potatoes, and eggplant (aubergine). It is native to Europe, North Africa, and Western Asia. Its distribution extends from Great Britain in the west to western Ukraine and the Iranian province of Gilan in the east. It is also naturalised or introduced in some parts of Canada and the United States.
The foliage and berries are extremely toxic when ingested, containing tropane alkaloids. These toxins include atropine, scopolamine and hyoscyamine, which cause delirium and hallucinations, and are also used as pharmaceutical anticholinergics. These tropane alkaloids appear to be common in the family Solanaceae, as they are also present in plants of the genera Brugmansia, Datura and Hyoscyamus, of the same family but in different subfamilies and tribes than the nightshade.
Atropa belladonna has a long history of use as a medicine, cosmetic, and poison. Known originally under various folk names (such as "deadly nightshade" in English), the plant was baptized Atropa belladonna by Carl Linnaeus (1707-1778) when he devised his classification system. He chose the genus name Atropa because of the poisonous properties of these plants. Atropos was the name of one of the Three Fates in Greek mythology, the one who cuts the thread of life after her sisters have spun and measured it. (Her name literally means "without a way forward" in Greek.) Linnaeus chose the species name belladonna ("beautiful woman" in Italian) in reference to the cosmetic use of the plant during the Renaissance, when women used the juice of the berries in eyedrops intended to dilate the pupils and make the eyes appear more seductive.
Extracts of plants in the deadly nightshade family have been in use since at least the 4th century BC, when Mandragora (mandrake) was recommended by Theophrastus for treatment of wounds, gout, and sleeplessness, and as a love potion. In the first century BC, Cleopatra used Atropine-rich extracts from the Egyptian henbane plant (another nightshade) for the above-mentioned purpose of dilating the pupils of her eyes.
The use of deadly nightshades as a poison was known in ancient Rome, as attested by the rumor that the Roman empress Livia Drusilla used the juice of Atropa belladonna berries to murder her husband, the emperor Augustus.
In the first century A.D. Dioscorides recognized wine of mandrake as an anaesthetic for treatment of pain or sleeplessness, to be given prior to surgery or cautery. The use of nightshade preparations for anesthesia, often in combination with opium, persisted throughout the Roman and Islamic Empires and continued in Europe until superseded in the 19th century by modern anesthetics.
The modern pharmacological study of Atropa belladonna extracts was begun by the German chemist Friedlieb Ferdinand Runge (1795–1867). In 1831, the German pharmacist Heinrich F. G. Mein (1799-1864) succeeded in preparing a pure crystalline form of the active substance, baptized atropine. 
Atropa belladonna is a branching herbaceous perennial rhizomatous hemicryptophyte, often growing as a subshrub from a fleshy rootstock. Plants grow to 2 m (7 ft) tall with ovate leaves 18 cm (7 in) long. The bell-shaped flowers are dull purple with green tinges and faintly scented. The fruits are berries, which are green, ripening to a shiny black, and approximately 1.5 cm (0.6 in) in diameter. The berries are sweet and are consumed by animals that disperse the seeds in their droppings, even though they contain toxic alkaloids. (See Toxicity) There is a pale-yellow flowering form called Atropa belladonna var. lutea with pale yellow fruit.
Atropa belladonna is native to temperate southern, Central and Eastern Europe; North Africa, Turkey, Iran and the Caucasus, but has been cultivated and introduced outside its native range. In southern Sweden it was recorded in Flora of Skåne in 1870 as grown in apothecary gardens near Malmö.
In Britain it is native only on calcareous soils, on disturbed ground, field margins, hedgerows and open woodland. More widespread as an alien, it is often a relic of cultivation as a medicinal herb. Seed is spread mainly by birds.
It is naturalized in parts of North America, where it is often found in shady, moist locations with limestone-rich soils. It is considered a weed species in parts of the world, where it colonizes areas with disturbed soils.
Atropa belladonna is rarely used in gardens, but, when grown, it is usually for its large upright habit and showy berries. Germination of the small seeds is often difficult, due to hard seed coats that cause seed dormancy. Germination takes several weeks under alternating temperature conditions, but can be sped up with the use of gibberellic acid. The seedlings need sterile soil to prevent damping off and resent root disturbance during transplanting.
Atropa belladonna is in the nightshade family (Solanaceae), which it shares with potatoes, tomatoes, eggplants, jimsonweed, tobacco, wolfberry, and chili peppers. The common names for this species include belladonna, deadly nightshade, divale, dwale, banewort, devil's berries, death cherries, beautiful death, devil's herb, great morel, and dwayberry.
The name Atropa belladonna was published by Carl Linnaeus in Species Plantarum in 1753. Atropa is derived from the name of the Greek goddess Atropos ('she who may not be turned aside' i.e. 'the inflexible' or 'the implacable')—one of the three Greek fates or destinies who would determine the course of a man's life by the weaving of threads that symbolized his birth, the events in his life, and finally his death, with Atropos cutting these threads to mark the last of these. The name "belladonna" comes from the Italian language, meaning 'beautiful lady'; originating either from its usage as a cosmetic to beautify pallid skin, or more probably, from its usage to increase the pupil size in women.
Belladonna is one of the most toxic plants found, and its use by mouth increases risk in numerous clinical conditions, such as complications of pregnancy, cardiovascular diseases, gastrointestinal disorders, and psychiatric disorders, among others. All parts of the plant contain tropane alkaloids. Roots have up to 1.3%, leaves 1.2%, stalks 0.65%, flowers 0.6%, ripe berries 0.7%, and seeds 0.4% tropane alkaloids;[clarification needed] leaves reach maximal alkaloid content when the plant is budding and flowering, roots are most poisonous in the end of the plant's vegetation period. Belladonna nectar is transformed by bees into honey that also contains tropane alkaloids. The berries pose the greatest danger to children because they look attractive and have a somewhat sweet taste. The root of the plant is generally the most toxic part, though this can vary from one specimen to another.
The active agents in belladonna, atropine, hyoscine (scopolamine), and hyoscyamine, have anticholinergic properties. The symptoms of belladonna poisoning include dilated pupils, sensitivity to light, blurred vision, tachycardia, loss of balance, staggering, headache, rash, flushing, severely dry mouth and throat, slurred speech, urinary retention, constipation, confusion, hallucinations, delirium, and convulsions. In 2009, A. belladonna berries were mistaken for blueberries by an adult woman; the six berries she ate were documented to result in severe anticholinergic syndrome. The plant's deadly symptoms are caused by atropine's disruption of the parasympathetic nervous system's ability to regulate involuntary activities, such as sweating, breathing, and heart rate. The antidote for belladonna poisoning is an anticholinesterase (such as physostigmine or pilocarpine), the same as for atropine.
Atropa belladonna is also toxic to many domestic animals, causing narcosis and paralysis. However, cattle and rabbits eat the plant seemingly without suffering harmful effects. In humans, its anticholinergic properties will cause the disruption of cognitive capacities, such as memory and learning.
Belladonna cultivation is legal in Southern and Eastern Europe, Pakistan, North America, and Brazil. Belladonna leaves and roots can be bought with a medical prescription in pharmacies throughout Germany. In the United States, there is only one approved prescription drug containing belladonna alkaloids such as atropine, and the FDA regards any over-the-counter products claiming efficacy and safety as an anticholinergic drug to be illegal.
The common name belladonna originates from its historic use by women, as bella donna is Italian for "beautiful lady". Drops prepared from the belladonna plant were used to dilate women's pupils, an effect considered to be attractive and seductive. Belladonna drops act as a muscarinic antagonist, blocking receptors in the muscles of the eye that constrict pupil size. Belladonna is currently rarely used cosmetically, as it carries the adverse effects of causing minor visual distortions, inability to focus on near objects, and increased heart rate. Prolonged usage was reputed to cause blindness.
In the United States, belladonna is marketed as a dietary supplement, typically as an atropine ingredient in over-the-counter cold medicine products. Although such cold medicine products are probably safe for oral use at typical atropine dosages (0.2 milligram), there is inadequate scientific evidence to assure their effectiveness. By FDA guidelines for supplements, there are no regulated manufacturing standards for cold medicines containing atropine, with some belladona supplements found to contain contaminants.
Scientific evidence to recommend the use of A. belladonna in its natural form for any condition is insufficient, although some of its components, in particular l-atropine, which was purified from belladonna in the 1830s, have accepted medical uses. Donnatal is a prescription pharmaceutical, that combines natural belladonna alkaloids in a specific, fixed ratio with phenobarbital to provide peripheral anticholinergic or antispasmodic action and mild sedation. Donnatal contains 0.0194 mg of atropine. According to the FDA and Donnatal labeling, it is possibly effective for use as adjunctive therapy in the treatment of irritable bowel syndrome (irritable colon, spastic colon, mucous colitis) and acute enterocolitis. Donnatal is not approved by the FDA as being either safe or effective. According to the FDA, Donnatal use has significant risks: it can cause harm to a fetus if administered to a pregnant woman, can lead to heat prostration if used in hot climates, may cause constipation, and may produce drowsiness or blurred vision.
Alternative medicine and toxicity risk
Belladonna has been used in herbal medicine for centuries as a pain reliever, muscle relaxer, and anti-inflammatory, and to treat menstrual problems, peptic ulcer disease, histaminic reaction, and motion sickness.
At least one 19th-century eclectic medicine journal explained how to prepare a belladonna tincture for direct administration. In homeopathic practices, belladonna was prescribed by German physician Samuel Hahnemann as a topical medication for inflammation and pain. In the form of Doktor Koster's Antigaspills, belladonna was a homeopathic medication for upset stomach and excessive flatulence. There is insufficient scientific evidence justifying the use of belladonna for these or any other clinical disorders.
In 2010 and 2016, the US Food and Drug Administration warned consumers against the use of homeopathic teething tablets and gels containing belladonna as used for infants and children, stating that the products may be toxic, causing "seizures, difficulty breathing, lethargy, excessive sleepiness, muscle weakness, skin flushing, constipation, difficulty urinating, or agitation".
Atropa belladonna and related plants, such as Datura stramonium (commonly known as jimson weed), have occasionally been used as recreational drugs because of the vivid hallucinations and delirium they produce. These hallucinations are most commonly described as very unpleasant, and recreational use is considered extremely dangerous because of the high risk of unintentional fatal overdose. The main psychoactive ingredients are the alkaloids scopolamine, and to a lesser extent, hyoscyamine. The effects of atropine on the central nervous system include memory disruption, which may lead to severe confusion. The major effects of belladonna consumption last for three to four hours; visual hallucinations can last for three to four days, and some negative aftereffects are preserved for several days.
The tropane alkaloids of A. belladonna were used as poisons, and early humans made poisonous arrows from the plant. In Ancient Rome, it was used as a poison by Agrippina the Younger, wife of Emperor Claudius on the advice of Locusta, a woman who specialized in poisons, and Livia, who is rumored to have used it to kill her husband Emperor Augustus.
Macbeth of Scotland, when he was still one of the lieutenants of King Duncan I of Scotland, used it during a truce to poison the troops of the invading Harold Harefoot, King of England, to the point that the English troops were unable to stand their ground and had to retreat to their ships.
In the past, witches were believed to use a mixture of belladonna, opium poppy and other plants, typically poisonous (such as monkshood and poison hemlock), in flying ointment, which they allegedly applied to help them fly to gatherings with other witches or to experience bacchanalian carousal. Carlo Ginzburg and others have argued that flying ointments were preparations meant to encourage hallucinatory dreaming; a possible explanation for the inclusion of belladonna and opium poppy in flying ointments concerns the known antagonism between tropane alkaloids of belladonna (scopolamine) and opiate alkaloids in the opium poppy, Papaver somniferum (to be specific, morphine), which produces a dream-like waking state (hypnagogia) or potentiated dreams while the user is asleep. This antagonism was known in folk medicine, discussed in traditional medicine formularies. The belladonna herb was also notable for its unpredictable effects from toxicity.
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