CAS Number
PubChem CID
Chemical and physical data
Formula C25H36O2
Molar mass 368.551 g/mol g·mol−1
3D model (JSmol)

AMG-41 (part of the AM cannabinoid series) is an analgesic drug which is a cannabinoid agonist. It is a derivative of Δ8-THC substituted with a cyclopropyl group on the C1′-position of the C3-alkyl side chain. AMG-41 is a potent agonist at both CB1 and CB2, with a Ki of 0.44 nM at CB1 vs 0.86 nM at CB2.[1][2][3]

See also[edit]


  1. ^ Papahatjis DP, Nikas SP, Andreou T, Makriyannis A. Novel 1′,1′-chain substituted Delta(8)-tetrahydrocannabinols. Bioorganic & Medicinal Chemistry Letters. 2002 Dec 16;12(24):3583-6. PMID 12443781
  2. ^ Papahatjis DP, et al. Pharmacophoric requirements for the cannabinoid side chain. Probing the cannabinoid receptor subsite at C1′. Journal of Medicinal Chemistry. 2003 Jul 17;46(15):3221-9. PMID 12852753
  3. ^ Papahatjis DP, et al. C1′-cycloalkyl side chain pharmacophore in tetrahydrocannabinols. Journal of Medicinal Chemistry. 2007 Aug 23;50(17):4048-60. PMID 17672444