PF-3845 structure.png
Clinical data
ATC code
  • None
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CAS Number
PubChem CID
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Chemical and physical data
Molar mass456.459 g/mol g·mol−1
3D model (JSmol)

PF-3845 is a selective inhibitor of fatty acid amide hydrolase.[1] It results in increased levels of anandamide and results in cannabinoid receptor-based effects. It has anti-inflammatory action in mice colitis models. Antidiarrheal and antinociceptive effects were also seen in mouse models of pain.[2]

A 2017 study published in the Journal of Psychiatry and Neuroscience found that PF-3845 exerts rapid and long-lasting anti-anxiety effects in mice exposed acutely to stress or chronically to the stress hormone corticosterone.[3]


  1. ^ Ahn, K; Johnson, DS; Mileni, M; Beidler, D; Long, JZ; McKinney, MK; Weerapana, E; Sadagopan, N; Liimatta, M; Smith, SE; Lazerwith, S; Stiff, C; Kamtekar, S; Bhattacharya, K; Zhang, Y; Swaney, S; Van Becelaere, K; Stevens, RC; Cravatt, BF (24 April 2009). "Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain". Chemistry & Biology. 16 (4): 411–20. doi:10.1016/j.chembiol.2009.02.013. PMC 2692831. PMID 19389627.
  2. ^ Fichna, J.; Sałaga, M.; Stuart, J.; Saur, D.; Sobczak, M.; Zatorski, H.; Timmermans, J.-P.; Bradshaw, H. B.; Ahn, K. (2014-04-01). "Selective inhibition of FAAH produces antidiarrheal and antinociceptive effect mediated by endocannabinoids and cannabinoid-like fatty acid amides". Neurogastroenterology & Motility. 26 (4): 470–481. doi:10.1111/nmo.12272. ISSN 1365-2982. PMID 24460851.
  3. ^ Duan, Tingting; Gu, Ning; Wang, Ying; Wang, Feng; Zhu, Jie; Fang, Yiru; Shen, Yuan; Han, Jing; Zhang, Xia (2017). "Fatty acid amide hydrolase inhibitors produce rapid anti-anxiety responses through amygdala long-term depression in male rodents". Journal of Psychiatry and Neuroscience. 42 (4): 230–241. doi:10.1503/jpn.160116. PMC 5487270. PMID 28234213.