|Chemical and physical data|
|Molar mass||373.462 g/mol g·mol−1|
|3D model (JSmol)|
MAM-2201 (4′-methyl-AM-2201, 5″-fluoro-JWH-122) is a drug that presumably acts as a potent agonist for the cannabinoid receptors. It had never previously been reported in the scientific or patent literature, and was first identified by laboratories in the Netherlands and Germany in June 2011 as an ingredient in synthetic cannabis smoking blends. Like RCS-4 and AB-001, MAM-2201 thus appears to be a novel compound invented by “research chemical” suppliers specifically for grey-market recreational use. Structurally, MAM-2201 is a hybrid of two known cannabinoid compounds JWH-122 and AM-2201, both of which had previously been used as active ingredients in synthetic cannabis blends before being banned in many countries.
A study of MAM-2201 in rats showed that it causes neurofunctional disruptions.
As of October 2015 MAM-2201 is a controlled substance in China.
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- Zaitsu, K; Hayashi, Y; Suzuki, K; Nakayama, H; Hattori, N; Takahara, R; Kusano, M; Tsuchihashi, H; Ishi, A (2015). “Metabolome disruption of the rat cerebrum induced by the acute toxic effects of the synthetic cannabinoid MAM-2201”. Life Sciences. 137: 49–55. doi:10.1016/j.lfs.2015.05.013. PMID 26032255.
- Temporary Class Drug Notice, 5 July 2012. NZ Department of Internal Affairs.
- “关于印发《非药用类麻醉药品和精神药品列管办法》的通知” (in Chinese). China Food and Drug Administration. 27 September 2015. Retrieved 1 October 2015.