CID-16020046

CID-16020046
CID16020046 structure.png
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
ECHA InfoCard100.233.214 Edit this at Wikidata
Chemical and physical data
FormulaC25H19N3O4
Molar mass425.435 g·mol−1
3D model (JSmol)

CID-16020046 is a compound which acts as an inverse agonist at the former orphan receptor GPR55, and may be the first selective inverse agonist characterised for this receptor. It was found to block a number of GPR55 mediated responses such as wound healing and activation of immune system T-cells and B-cells, as well as showing inverse agonist activity in the absence of GPR55 agonist stimulation. However while it was found to have good selectivity over the related CB1 and CB2 cannabinoid receptors as well as a number of other targets, CID-16020046 has not yet been tested against another related receptor GPR18, so its selectivity for GPR55 over this target has not been established.[1]

See also[edit]

References[edit]

  1. ^ Kargl J, Brown AJ, Andersen L, Dorn G, Schicho R, Waldhoer M, Heinemann A (July 2013). "A selective antagonist reveals a potential role of G protein-coupled receptor 55 in platelet and endothelial cell function". The Journal of Pharmacology and Experimental Therapeutics. 346 (1): 54–66. doi:10.1124/jpet.113.204180. PMID 23639801.