IW-2143 molecular structure.png
Clinical data
ATC code
  • none
Legal status
Legal status
  • Investigational
CAS Number
PubChem CID
Chemical and physical data
Molar mass317.389 g·mol−1
3D model (JSmol)

BNC210 (also known as IW-2143 during its time licensed to Ironwood Pharmaceuticals) is an anxiolytic drug that acts via negative allosteric modulation of the α7-nicotinic acetylcholine receptor,[1] by Bionomics Limited. It is currently being investigated for the treatment of post traumatic stress disorder.[2] The drug has demonstrated clinically significant anxiety reduction in both animal models and in Phase I trials.[3]

It appears to be devoid of significant sedation or memory-impairing side effects, as well as lacking addictive potential in rat discriminatory models.[4]

Phase I trials have shown no serious side effects.

Bionomics previously licensed it to Ironwood Pharmaceuticals in January 2012, where it was known as IW-2143. In December 2012, IW-2143 begun undergoing phase I clinical trials in the United States,[5] but in November 2014, was released back to Bionomics in a mutual agreement.[6] Bionomics will now continue development and clinical testing, with Ironwood receiving a royalty for their work done.

As of April 2015, BNC210 is in phase II clinical trials.[7] The estimated study completion date is September 2018. [2]

Study Details[edit]

The clinical trial is currently testing twice daily oral dosages of 600 mg, 300 mg, and 150 mg, for 12 weeks. [2] The primary objective of the trial is for the treatment of PTSD with a secondary objective for the effectiveness in treating anxiety disorders and depression. [2]

See also[edit]


  1. ^
  2. ^ a b c d "" (HTML). Retrieved 2018-01-04.
  3. ^ "Bionomics - Pipeline". Retrieved 2010-11-09. Bionomics has discovered a novel compound, BNC210, that offers dramatic competitive advantages over existing treatments
  4. ^ O'Connor, S.; Andriambeloson, E.; Huyard, B.; Wagner, S.; Sleebs, B.; Quasi, N.; Bui, C.; Street, I. "BNC210: A Novel Compound with Potent Anxiolytic Activity" (PDF). Bionomics Limited. Retrieved 2010-11-09. By applying a targeted medicinal chemistry strategy beginning from a compound cited in the literature, Bionomics has developed BNC210
  5. ^ "Archived copy". Archived from the original on 2014-05-04. Retrieved 2013-02-01.CS1 maint: archived copy as title (link)
  6. ^
  7. ^ Bionomics Limited. "" (HTML). PRNewswire. Retrieved 2015-06-10.