Activating protein 2

transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
Symbol TFAP2A
Alt. symbols TFAP2, AP2TF
Entrez 7020
HUGO 11742
OMIM 107580
RefSeq NM_003220
UniProt P05549
Other data
Locus Chr. 6 p22.3
transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
Symbol TFAP2B
Alt. symbols AP2-B
Entrez 7021
HUGO 11743
OMIM 601601
RefSeq NM_003221
UniProt Q92481
Other data
Locus Chr. 6 p12
transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
Symbol TFAP2C
Entrez 7022
HUGO 11744
OMIM 601602
RefSeq NM_003222
UniProt Q92754
Other data
Locus Chr. 20 q13.2
transcription factor AP-2 delta (activating enhancer binding protein 2 delta)
Symbol TFAP2D
Alt. symbols TFAP2BL1
Entrez 83741
HUGO 15581
OMIM 610161
RefSeq NM_172238
UniProt Q7Z6R9
Other data
Locus Chr. 6 p12.3
transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon)
Symbol TFAP2E
Alt. symbols AP2E
Entrez 339488
HUGO 30774
RefSeq NM_178548
UniProt Q6VUC0
Other data
Locus Chr. 1 p34.3

Activating Protein 2 (AP-2) is a family of closely related transcription factors[1][2] which plays a critical role in regulating gene expression during early development.[3]


  1. ^ Williams T, Tjian R (1991). “Characterization of a dimerization motif in AP-2 and its function in heterologous DNA-binding proteins”. Science. 251 (4997): 1067–71. doi:10.1126/science.1998122. PMID 1998122.
  2. ^ Williams T, Tjian R (1991). “Analysis of the DNA-binding and activation properties of the human transcription factor AP-2”. Genes Dev. 5 (4): 670–82. doi:10.1101/gad.5.4.670. PMID 2010091.
  3. ^ Hilger-Eversheim K, Moser M, Schorle H, Buettner R (2000). “Regulatory roles of AP-2 transcription factors in vertebrate development, apoptosis and cell-cycle control”. Gene. 260 (1–2): 1–12. doi:10.1016/S0378-1119(00)00454-6. PMID 11137286.

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