Žydrūnas is a Lithuanian masculine given name and may refer to:
- Žydrūnas Ilgauskas (born 1975), retired Lithuanian professional basketball player and assistant general manager for the Cleveland Cavaliers
- Žydrūnas Karčemarskas (born 1983), Lithuanian professional footballer currently playing for Turkish club Gaziantepspor
- Žydrūnas Savickas (born 1975), Lithuanian strongman
- Žydrūnas Savickas (born 1991), Lithuanian racing cyclist
- Žydrūnas Urbonas (born 1976), Lithuanian professional basketball player currently playing in Ukrainian championship for BC Donetsk