Wickham may refer to:

• Wickham, New South Wales, a suburb of Newcastle
• Wickham, Northern Territory, a locality
• Wickham, Western Australia, a town
• Wickham River, an ephemeral river in the Northern Territory

• Wickham Parish, New Brunswick
  • Wickham, New Brunswick, an unincorporated community therein
• Wickham, Quebec

• Wickham, Berkshire
• Wickham, Hampshire
• Wickham Bishops, Essex
• Wickham Market, Suffolk
• Wickham Skeith, Suffolk
• Wickham St. Paul, Essex
• East Wickham, south-east London
• West Wickham, Cambridgeshire
• West Wickham, south-east London

• Wickham, West Virginia, an unincorporated community
• Wickham, Hampshire County, West Virginia, a former unincorporated community

• Wickham Island (disambiguation)

• Wickham Skinner, professor at the Harvard Business School

• Anna Wickham (1884–1947), pseudonym of Edith Mary Harper, English poet
• Archie Wickham (1855–1935), English cricketer, Anglican clergyman and entomologist
• Charles Wickham (police officer) (1879–1971), commander of the Royal Ulster Constabulary
• Charles Preston Wickham (1836–1925), American congressman from Ohio
• Christopher Wickham (born 1950), Chichele Professor of Medieval History at Oxford
• Connor Wickham (born 1993), English footballer
• David Wickham (born 1966), British pianist, conductor and music director
• Edward Wickham (1890–1957), British Conservative politician
• Enoch Tanner Wickham (1883–1970), American folk artist
• Florence Wickham (1880–1962), American operatic contralto
• Geoffrey Wickham (born 1933), Australian pioneer of cardiac pacemaking, co-founder of Telectronics
• Glynne Wickham (1922–2004), British Shakespearean and theatre scholar
• Hadley Wickham, New Zealand statistician
• Henry Wickham (explorer) (1846–1928), British explorer
• Henry Wickham Wickham (1800–1876), British Conservative politician
• Joe Wickham (1890–1968), General Secretary of the Football Association of Ireland
• John Wickham (attorney) (1736–1839), American attorney
• John A. Wickham, Jr. (born 1928), retired US Army general and Chief of Staff (1983–87)
• John Clements Wickham (1798–1864), Australian naval officer on Darwin's HMS Beagle and judge in Queensland
• Joseph Dresser Wickham (1797–1891), American minister
• Joseph H. Wickham (1911–2000), American politician
• Keith Wickham (born 1965), British voice actor
• Kevin Wickham (1939–2020), Australian rower
• Louis Frédéric Wickham (1861–1913), French physician and pathologist
• Madeleine Wickham (born 1969), British author of chick lit as Sophie Kinsella
• Nick Wickham, British film and television director
• Parker Wickham (1727–1785), New York Loyalist politician
• Phil Wickham (born 1984), American Christian musician
• Reginald Wickham (1871–1952), English cricketer
• Saskia Wickham (born 1967), British actress
• Steve Wickham, Irish musician
• Ted Wickham (1911–1994), Bishop of Middleton from 1959 to 1982
• Tracey Wickham (born 1962), Australian swimmer
• Vicki Wickham (born 1939), English talent manager
• Vincent Schofield Wickham (1894–1968), American graphic artist and sculptor
• William Wickham (bishop) (1539–1595), English bishop
• William Wickham (1761–1840), British politician
• William H. Wickham (1832–1893), mayor of New York (1875–76)
• Williams Carter Wickham (1820–1888), Confederate brigadier general and Virginian politician

• Bobbie Wickham, in P. G. Wodehouse's Jeeves stories
• George Wickham, principal villain in Jane Austen's 1813 novel Pride and Prejudice
• William Wickham, a recurring character of Poldark fifth season

• Wickham A Bluebird, a home-built aircraft
• Wickhams (department store) (now closed), in London
• Wickham railway station (disambiguation)
• Wickham trolley, a railway engineering personnel carrier
• Wickham striae, a skin condition named after Louis Frédéric Wickham

• Wicken (disambiguation)
• Grevillea wickhamii, an Australian plant also known as Wickham's Grevillea
• Whickham, Tyne and Wear, England
• Wykeham (disambiguation)
• Wycombe