VDB or VdB may refer to:

• Alexander Van der Bellen, current President of Austria.
• Victor David Brenner, designer of U.S. one-cent coin bearing Abraham Lincoln's image.
• Paul Vanden Boeynants, Belgian prime minister.
• Frank Vandenbroucke (cyclist)
• Vicente del Bosque, former Spanish footballer, currently manager of the Spain national football team.
• Donny van de Beek, Dutch footballer playing for Manchester United.

• dBV, voltage measurement on a decibel scale
• VDB Catalog, list of reflection nebulae compiled by Sidney van den Bergh
• Video Data Bank, video art distribution service of the Art Institute of Chicago

• dBase, abbreviated as VdB
• /var/db/pkg, the installed package database in FreeBSD and Gentoo Linux

• VDB, IATA code for Fagernes Airport, Leirin, Norway
• Volksdeutsche Bewegung, a former political party in Luxembourg
• Vrijzinnig Democratische Bond, a Dutch political party
• Verband der Berufsringer, a defunct German professional wrestling promotion