Protein-coding gene in the species Homo sapiens
Synaptic vesicle membrane protein VAT-1 homolog is a protein that in humans is encoded by the VAT1 gene .[ 5] [ 6] [ 7]
Synaptic vesicles are responsible for regulating the storage and release of neurotransmitters in the nerve terminal. The protein encoded by this gene is an abundant integral membrane protein of cholinergic synaptic vesicles and is thought to be involved in vesicular transport . It belongs to the quinone oxidoreductase subfamily of zinc-containing alcohol dehydrogenase proteins.[ 7]
In melanocytic cells VAT1 gene expression may be regulated by MITF .[ 8]
^ a b c GRCh38: Ensembl release 89: ENSG00000108828 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034993 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
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^ Smith TM, Lee MK, Szabo CI, Jerome N, McEuen M, Taylor M, Hood L, King MC (Feb 1997). "Complete genomic sequence and analysis of 117 kb of human DNA containing the gene BRCA1" . Genome Res . 6 (11): 1029–49. doi :10.1101/gr.6.11.1029 . PMID 8938427 .
^ a b "Entrez Gene: VAT1 vesicle amine transport protein 1 homolog (T. californica)" .
^ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy" . Pigment Cell Melanoma Res . 21 (6): 665–76. doi :10.1111/j.1755-148X.2008.00505.x . PMID 19067971 . S2CID 24698373 .
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