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Trade names | Lepticur |
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Formula | C22H23NS |
Molar mass | 333.49 g·mol−1 |
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Tropatepine (brand name Lepticur) is an anticholinergic used as an antiparkinsonian agent.[1]
Synthesis
[edit]Tropatepine can be synthesized from 3-chlorotropane (1).[2] A Grignard reaction between 3-chlorotropane and dibenzo[b,e]thiepin-11(6H)-one (2) followed by dehydration to the olefin produces tropatepine (3).
![](https://upload.wikimedia.org/wikipedia/commons/thumb/c/cd/Tropatepine_synthesis.svg/300px-Tropatepine_synthesis.svg.png)
See also
[edit]References
[edit]- ^ Celsis P, Montastruc JL, Rascol O, Senard JM, Marc-Vergnes JP, Rascol A (July 1989). "Effect of tropatepine, an anticholinergic drug, on regional cerebral blood flow in patients with Parkinson's disease". Journal of Neurology, Neurosurgery, and Psychiatry. 52 (7): 917–8. doi:10.1136/jnnp.52.7.917. PMC 1031949. PMID 2769291.
- ^ DE1952206 idem J Boissier, R Ratouis, U.S. patent 3,725,415 (1973 to Ind Pour La Fab Antibiotiques).