Game of the Century may refer to:
Sports[edit]
- The Game of the Century (chess), a chess game between Donald Byrne and Bobby Fischer in 1956
- Game of the Century (college basketball), a basketball game between the Houston Cougars and UCLA Bruins in 1968
- Game of the Century (college football), any one of several games in U.S. college football
- Italy v West Germany (1970 FIFA World Cup), the semi-final of the 1970 FIFA World Cup between Italy and West Germany
- The Game of the Century (Go), a game of Go between Honinbo Shusai and Go Seigen in 1934
- The Game of the Century (rugby union), a 1905 match between Wales and New Zealand, also known as the Match of the Century
Television[edit]
- The Game of the Century (TV series), 1978 British TV series