Recombination signal binding protein for immunoglobulin kappa J region is a protein that in humans is encoded by the RBPJ gene.[5][6][7]
RBPJ[8] also known as CBF1, is the human homolog for the Drosophila gene Suppressor of Hairless. Its promoter region is classically used to demonstrate Notch1 signaling.[9]
Interactions
[edit]RBPJ has been shown to interact with:
References
[edit]- ^ a b c GRCh38: Ensembl release 89: ENSG00000168214 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039191 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Amakawa R, Jing W, Ozawa K, et al. (August 1993). "Human Jk recombination signal binding protein gene (IGKJRB): comparison with its mouse homologue". Genomics. 17 (2): 306–315. doi:10.1006/geno.1993.1326. PMID 8406481.
- ^ Tang X, Saito-Ohara F, Song J, et al. (June 1997). "Assignment of the human gene for KBF2/RBP-Jk to chromosome 9p12-13 and 9q13 by fluorescence in situ hybridization". The Japanese Journal of Human Genetics. 42 (2): 337–341. doi:10.1007/BF02766956. PMID 9290259.
- ^ "NCBI Gene: RBPJ recombination signal binding protein for immunoglobulin kappa J region".
- ^ "HGNC: RBPJ Symbol Report".
- ^ Hsieh JJ, Henkel T, Salmon P, et al. (March 1996). "Truncated mammalian Notch1 activates CBF1/RBPJk-repressed genes by a mechanism resembling that of Epstein-Barr virus EBNA2". Molecular and Cellular Biology. 16 (3): 952–959. doi:10.1128/mcb.16.3.952. PMC 231077. PMID 8622698.
- ^ Nam Y, Weng AP, Aster JC, et al. (June 2003). "Structural requirements for assembly of the CSL.intracellular Notch1.Mastermind-like 1 transcriptional activation complex". The Journal of Biological Chemistry. 278 (23): 21232–21239. doi:10.1074/jbc.M301567200. PMID 12644465.
- ^ Aster JC, Robertson ES, Hasserjian RP, et al. (April 1997). "Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription". The Journal of Biological Chemistry. 272 (17): 11336–11343. doi:10.1074/jbc.272.17.11336. PMID 9111040.
- ^ Beatus P, Lundkvist J, Oberg C, et al. (June 2001). "The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity". Mechanisms of Development. 104 (1–2): 3–20. doi:10.1016/s0925-4773(01)00373-2. PMID 11404076. S2CID 9526831.
- ^ Zhou S, Hayward SD (September 2001). "Nuclear localization of CBF1 is regulated by interactions with the SMRT corepressor complex". Molecular and Cellular Biology. 21 (18): 6222–6232. doi:10.1128/mcb.21.18.6222-6232.2001. PMC 87339. PMID 11509665.
- ^ Kurooka H, Honjo T (June 2000). "Functional interaction between the mouse notch1 intracellular region and histone acetyltransferases PCAF and GCN5". The Journal of Biological Chemistry. 275 (22): 17211–17220. doi:10.1074/jbc.M000909200. PMID 10747963.
- ^ a b Zhou S, Fujimuro M, Hsieh JJ, et al. (February 2000). "A role for SKIP in EBNA2 activation of CBF1-repressed promoters". Journal of Virology. 74 (4): 1939–1947. doi:10.1128/jvi.74.4.1939-1947.2000. PMC 111672. PMID 10644367.
- ^ Hsieh JJ, Zhou S, Chen L, et al. (January 1999). "CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex". Proceedings of the National Academy of Sciences of the United States of America. 96 (1): 23–28. Bibcode:1999PNAS...96...23H. doi:10.1073/pnas.96.1.23. PMC 15086. PMID 9874765.
- ^ Zhou S, Fujimuro M, Hsieh JJ, et al. (April 2000). "SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function". Molecular and Cellular Biology. 20 (7): 2400–2410. doi:10.1128/mcb.20.7.2400-2410.2000. PMC 85419. PMID 10713164.
- ^ Overman J, Fontaine F, Wylie-Sears J, et al. (July 2019). van Lohuizen M, Koh GY, Ostergaard P (eds.). "R-propranolol is a small molecule inhibitor of the SOX18 transcription factor in a rare vascular syndrome and hemangioma". eLife. 8: e43026. doi:10.7554/eLife.43026. PMC 6667216. PMID 31358114.
- ^ Díaz-Trelles R, Scimia MC, Bushway P, et al. (June 2016). "Notch-independent RBPJ controls angiogenesis in the adult heart". Nature Communications. 7 (1): 12088. Bibcode:2016NatCo...712088D. doi:10.1038/ncomms12088. PMC 4931341. PMID 27357444.
Further reading
[edit]- Oka C, Kawaichi M (1995). "V(D)J recombination of immunoglobulin genes". Advances in Biophysics. 31: 163–180. doi:10.1016/0065-227X(95)99390-B. PMID 7625272.
- Matsunami N, Hamaguchi Y, Yamamoto Y, et al. (1990). "A protein binding to the J kappa recombination sequence of immunoglobulin genes contains a sequence related to the integrase motif". Nature. 342 (6252): 934–937. doi:10.1038/342934a0. PMID 2556644. S2CID 4370462.
- Tong X, Drapkin R, Yalamanchili R, et al. (September 1995). "The Epstein-Barr virus nuclear protein 2 acidic domain forms a complex with a novel cellular coactivator that can interact with TFIIE". Molecular and Cellular Biology. 15 (9): 4735–4744. doi:10.1128/mcb.15.9.4735. PMC 230717. PMID 7651391.
- Zhao B, Marshall DR, Sample CE (July 1996). "A conserved domain of the Epstein-Barr virus nuclear antigens 3A and 3C binds to a discrete domain of Jkappa". Journal of Virology. 70 (7): 4228–4236. doi:10.1128/JVI.70.7.4228-4236.1996. PMC 190353. PMID 8676443.
- Tamura K, Taniguchi Y, Minoguchi S, et al. (December 1995). "Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-J kappa/Su(H)". Current Biology. 5 (12): 1416–1423. Bibcode:1995CBio....5.1416T. doi:10.1016/S0960-9822(95)00279-X. hdl:2433/202204. PMID 8749394. S2CID 18442572.
- Gress TM, Müller-Pillasch F, Geng M, et al. (October 1996). "A pancreatic cancer-specific expression profile". Oncogene. 13 (8): 1819–1830. PMID 8895530.
- Hsieh JJ, Nofziger DE, Weinmaster G, et al. (March 1997). "Epstein-Barr virus immortalization: Notch2 interacts with CBF1 and blocks differentiation". Journal of Virology. 71 (3): 1938–1945. doi:10.1128/JVI.71.3.1938-1945.1997. PMC 191274. PMID 9032325.
- Aster JC, Robertson ES, Hasserjian RP, et al. (April 1997). "Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription". The Journal of Biological Chemistry. 272 (17): 11336–11343. doi:10.1074/jbc.272.17.11336. PMID 9111040.
- Kao HY, Ordentlich P, Koyano-Nakagawa N, et al. (August 1998). "A histone deacetylase corepressor complex regulates the Notch signal transduction pathway". Genes & Development. 12 (15): 2269–2277. doi:10.1101/gad.12.15.2269. PMC 317043. PMID 9694793.
- Hsieh JJ, Zhou S, Chen L, et al. (January 1999). "CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex". Proceedings of the National Academy of Sciences of the United States of America. 96 (1): 23–28. Bibcode:1999PNAS...96...23H. doi:10.1073/pnas.96.1.23. PMC 15086. PMID 9874765.
- Scanlan MJ, Gordan JD, Williamson B, et al. (November 1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". International Journal of Cancer. 83 (4): 456–464. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479.
- Callahan J, Aster J, Sklar J, et al. (January 2000). "Intracellular forms of human NOTCH1 interact at distinctly different levels with RBP-jkappa in human B and T cells". Leukemia. 14 (1): 84–92. doi:10.1038/sj.leu.2401630. PMID 10637481.
- Smith PR, de Jesus O, Turner D, et al. (April 2000). "Structure and coding content of CST (BART) family RNAs of Epstein-Barr virus". Journal of Virology. 74 (7): 3082–3092. doi:10.1128/JVI.74.7.3082-3092.2000. PMC 111807. PMID 10708423.
- Zhou S, Fujimuro M, Hsieh JJ, et al. (April 2000). "SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function". Molecular and Cellular Biology. 20 (7): 2400–2410. doi:10.1128/MCB.20.7.2400-2410.2000. PMC 85419. PMID 10713164.
- Kurooka H, Honjo T (June 2000). "Functional interaction between the mouse notch1 intracellular region and histone acetyltransferases PCAF and GCN5". The Journal of Biological Chemistry. 275 (22): 17211–17220. doi:10.1074/jbc.M000909200. PMID 10747963.
- Beatus P, Lundkvist J, Oberg C, et al. (June 2001). "The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity". Mechanisms of Development. 104 (1–2): 3–20. doi:10.1016/S0925-4773(01)00373-2. PMID 11404076. S2CID 9526831.
- Zhou S, Hayward SD (September 2001). "Nuclear localization of CBF1 is regulated by interactions with the SMRT corepressor complex". Molecular and Cellular Biology. 21 (18): 6222–6232. doi:10.1128/MCB.21.18.6222-6232.2001. PMC 87339. PMID 11509665.
External links
[edit]- RBPJ+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.