Pennsylvania Route 652, designated by the Pennsylvania Department of Transportation (PennDOT) as State Route 0652, is a 10.57-mile (17.01 km) long east–west state highway located in the northeast Pennsylvania county of Wayne. The western terminus of the route is at U.S. Route 6 (US 6) in the Texas Township community of Indian Orchard. The highways heads to the northeast, and reaches the eastern terminus at the New York–Pennsylvania border in Damascus Township, where Route 652 crosses the Narrowsburg–Darbytown Bridge over the Delaware River and into New York, continuing as New York State Route 52 and Sullivan County Route 24.

The highway originated as the easternmost stretch of US 106 when the United States Highway System was first put together in 1926. The route, however, was assigned as a state highway in 1920. Route 652 was once used south of the alignment, in the northern suburbs in Philadelphia. Route 652 remained on that alignment until 1946, and in 1972, the 652 designation was reassigned onto US 106 alignment.

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