Interstate 40 (I-40) is an east–west Interstate Highway that has a 359.6-mile (578.72 km) section in the U.S. state of Arizona connecting sections in California to New Mexico. It enters Arizona from the west at a crossing of the Colorado River southwest of Kingman. It travels eastward across the northern portion of the state connecting the cities of Kingman, Ash Fork, Williams, Flagstaff, Winslow, and Holbrook. I-40 continues into New Mexico, heading to Albuquerque. The highway has major junctions with U.S. Route 93 (US 93) in Kingman, the main highway connecting Phoenix and Las Vegas, Nevada, and I-17 in Flagstaff, the Interstate linking Phoenix and Flagstaff.

For the majority of its routing through Arizona, I-40 follows the historic alignment of U.S. Route 66. The lone exception is a stretch between Kingman and Ash Fork where US 66 took a more northerly, less direct route that is now State Route 66. Construction of I-40 was ongoing in the 1960s and 1970s and reached completion in 1984. With the completion of I-40 in 1984, the entire routing of US 66 had been bypassed by Interstate Highways which led to its decertification a year later in 1985.

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