U.S. Route 60 (US-60) is a transcontinental U.S. highway extending from near Brenda, Arizona to Virginia Beach, Virginia on the Atlantic Ocean. Along the way, 352.39 miles (567.12 km) of the route lies within the state of Oklahoma. The highway crosses into the state from Texas west of Arnett and serves many towns and cities in the northern part of the state, including Arnett, Seiling, Fairview, Enid, Ponca City, Pawhuska, Bartlesville, and Vinita. US-60 exits Oklahoma near Seneca, Missouri. The first 60.2 miles (96.9 km) of the route, from the Texas line to Seiling, is also designated as State Highway 51 (SH-51). US-60, as originally designated, did not enter Oklahoma. Instead, it ended in Springfield, Missouri, continuing east from there. AASHO approved an extension of US-60 on May 29, 1930, which extended it west through Oklahoma to Amarillo, Texas. US-60's extension displaced US-164 in its entirety; that designation was then retired.

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