Petrone is a surname, and may refer to:

• Epp Petrone (born 1974), Estonian writer, journalist, blogger, and publisher
• Francisco Petrone (1902–1967), Argentine actor
• Pedro Petrone (1904–1964), Uruguayan footballer
• Penny Petrone (1925–2005), Canadian writer, educator, patron of the arts, and philanthropist
• Rocco Petrone (1926–2006), American engineer
• Sonia Petrone, Italian mathematical statistician