No-Brainer or No Brainer may refer to:

• "The No-Brainer", the 12th episode of the television series Fringe
• "It's a No-Brainer", an episode of Mr. Show with Bob and David
• "No Brainer" (song), a 2018 song by DJ Khaled
• No Brainer, a 2008 film by Dave, Shelly and Chainsaw
• "No Brainer", an episode of the TV series Gadget & the Gadgetinis
• Diary of a Wimpy Kid: No Brainer, the eighteenth book in the Diary of a Wimpy Kid series