Chemical compound
"Thionylan" redirects here. Not to be confused with thionyl halides: thionyl fluoride, thionyl chloride and thionyl bromide.
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Formula | C14H19N3S |
Molar mass | 261.39 g·mol−1 |
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Methapyrilene is an antihistamine and anticholinergic of the pyridine chemical class which was developed in the early 1950s. It was sold under the trade names Co-Pyronil and Histadyl EC in the UK.[1] It has relatively strong sedative effects, to the extent that its primary use was as a medication for insomnia rather than for its antihistamine action. Together with scopolamine, it was the main ingredient in Sominex, Nytol, and Sleep-Eze. It also provided the sedative component of Excedrin PM.[2] All of these products were reformulated in the late 1970s[3] when methapyrilene was demonstrated to cause liver cancer in rats when given chronically.[4]
See also
[edit]References
[edit]- ^ "Archive". Birmingham Post. July 1979 – via The Free Library.
- ^ "FDA Seeks Restrictions On Sleeping Aid Drugs". Daily Press. Vol. 83, no. 164. 1978-06-13. p. 1 – via Newspapers.com.
- ^ Cook C (1979-06-28). "Sleep aids back with new drug | Critics assail 'human testing'". The Minneapolis Star. pp. 1A, 6A – via Newspapers.com.
- ^ Lijinsky W, Reuber MD, Blackwell BN (August 1980). "Liver tumors induced in rats by oral administration of the antihistaminic methapyrilene hydrochloride". Science. 209 (4458): 817–819. Bibcode:1980Sci...209..817L. doi:10.1126/science.7403848. PMID 7403848.
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