Route 275 or Highway 275 may refer to:

• Manitoba Provincial Road 275
• New Brunswick Route 275
• Quebec Route 275

• National Highway 275 (India)
• State Highway 275 (Maharashtra)

• Japan National Route 275

• Interstate 275 (multiple highways)
• U.S. Route 275
• Alabama State Route 275
• California State Route 275
• Connecticut Route 275
• Florida State Road 275 (former)
• Georgia State Route 275
• Maryland Route 275
• Minnesota State Highway 275
• Montana Secondary Highway 275
• New Mexico State Road 275
• New York State Route 275
• Tennessee State Route 275
• Texas State Highway 275
  • Texas State Highway Loop 275
  • Farm to Market Road 275 (Texas)
• Utah State Route 275