Protein-coding gene in the species Homo sapiens
LIM domain-binding protein 1 is a protein that in humans is encoded by the LDB1 gene .[5] [6] [7]
LDB1 has been shown to interact with other proteins such as LMO4 ,[8] [9] TCF3 ,[10] TAL1 [10] and CBFA2T3 .[10]
^ a b c GRCh38: Ensembl release 89: ENSG00000198728 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025223 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Yamashita T, Agulnick AD, Copeland NG, Gilbert DJ, Jenkins NA, Westphal H (Apr 1998). "Genomic structure and chromosomal localization of the mouse LIM domain-binding protein 1 gene, Ldb1" . Genomics . 48 (1): 87–92. doi :10.1006/geno.1997.5163 . PMID 9503020 .
^ Semina EV, Altherr MR, Murray JC (Dec 1998). "Cloning and chromosomal localization of two novel human genes encoding LIM-domain binding factors CLIM1 and CLIM2/LDB1/NLI". Mamm Genome . 9 (11): 921–4. doi :10.1007/s003359900899 . PMID 9799849 . S2CID 28813194 .
^ "Entrez Gene: LDB1 LIM domain binding 1" .
^ Sutherland KD, Visvader Jane E, Choong David Y H, Sum Eleanor Y M, Lindeman Geoffrey J, Campbell Ian G (Oct 2003). "Mutational analysis of the LMO4 gene, encoding a BRCA1-interacting protein, in breast carcinomas" . Int. J. Cancer . 107 (1): 155–8. doi :10.1002/ijc.11343 . ISSN 0020-7136 . PMID 12925972 . S2CID 20908722 .
^ Deane JE, Mackay Joel P, Kwan Ann H Y, Sum Eleanor Y M, Visvader Jane E, Matthews Jacqueline M (May 2003). "Structural basis for the recognition of ldb1 by the N-terminal LIM domains of LMO2 and LMO4" . EMBO J . 22 (9): 2224–33. doi :10.1093/emboj/cdg196 . ISSN 0261-4189 . PMC 156068 . PMID 12727888 .
^ a b c Goardon N, Lambert Julie A, Rodriguez Patrick, Nissaire Philippe, Herblot Sabine, Thibault Pierre, Dumenil Dominique, Strouboulis John, Romeo Paul-Henri, Hoang Trang (Jan 2006). "ETO2 coordinates cellular proliferation and differentiation during erythropoiesis" . EMBO J . 25 (2): 357–66. doi :10.1038/sj.emboj.7600934 . ISSN 0261-4189 . PMC 1383517 . PMID 16407974 .
Osada H, Grutz GG, Axelson H, et al. (1997). "LIM-only protein Lmo2 forms a protein complex with erythroid transcription factor GATA-1". Leukemia . 11 (Suppl 3): 307–12. PMID 9209374 .
Wadman IA, Osada H, Grütz GG, et al. (1997). "The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins" . EMBO J . 16 (11): 3145–57. doi :10.1093/emboj/16.11.3145 . PMC 1169933 . PMID 9214632 .
Jurata LW, Gill GN (1997). "Functional analysis of the nuclear LIM domain interactor NLI" . Mol. Cell. Biol . 17 (10): 5688–98. doi :10.1128/MCB.17.10.5688 . PMC 232417 . PMID 9315627 .
Visvader JE, Mao X, Fujiwara Y, et al. (1998). "The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation" . Proc. Natl. Acad. Sci. U.S.A . 94 (25): 13707–12. Bibcode :1997PNAS...9413707V . doi :10.1073/pnas.94.25.13707 . PMC 28370 . PMID 9391090 .
Jurata LW, Pfaff SL, Gill GN (1998). "The nuclear LIM domain interactor NLI mediates homo- and heterodimerization of LIM domain transcription factors" . J. Biol. Chem . 273 (6): 3152–7. doi :10.1074/jbc.273.6.3152 . PMID 9452425 .
Kenny DA, Jurata LW, Saga Y, Gill GN (1998). "Identification and characterization of LMO4, an LMO gene with a novel pattern of expression during embryogenesis" . Proc. Natl. Acad. Sci. U.S.A . 95 (19): 11257–62. Bibcode :1998PNAS...9511257K . doi :10.1073/pnas.95.19.11257 . PMC 21629 . PMID 9736723 .
Valge-Archer V, Forster A, Rabbitts TH (1999). "The LMO1 and LDB1 proteins interact in human T cell acute leukaemia with the chromosomal translocation t(11;14)(p15;q11)". Oncogene . 17 (24): 3199–202. doi :10.1038/sj.onc.1202353 . PMID 9872335 . S2CID 9835264 .
Ueki N, Seki N, Yano K, et al. (1999). "Isolation and chromosomal assignment of human genes encoding cofactor of LIM homeodomain proteins, CLIM1 and CLIM2" . J. Hum. Genet . 44 (2): 112–5. doi :10.1007/s100380050120 . PMID 10083735 .
Drechsler M, Schumacher V, Friedrich S, et al. (2000). "Genomic structure, alternative transcripts and chromosome location of the human LIM domain binding protein 1 gene LDB1". Cytogenet. Cell Genet . 87 (1–2): 119–24. doi :10.1159/000015377 . PMID 10640831 . S2CID 23735189 .
Dreyer SD, Morello R, German MS, et al. (2000). "LMX1B transactivation and expression in nail-patella syndrome" . Hum. Mol. Genet . 9 (7): 1067–74. doi :10.1093/hmg/9.7.1067 . PMID 10767331 .
Sum EY, Peng B, Yu X, et al. (2002). "The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity" . J. Biol. Chem . 277 (10): 7849–56. doi :10.1074/jbc.M110603200 . PMID 11751867 .
Ostendorff HP, Peirano RI, Peters MA, et al. (2002). "Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors". Nature . 416 (6876): 99–103. Bibcode :2002Natur.416...99O . doi :10.1038/416099a . PMID 11882901 . S2CID 4426785 .
Deane JE, Visvader JE, Mackay JP, Matthew JM (2003). "1H, 15N and 13C assignments of FLIN4, an intramolecular LMO4:ldb1 complex". J. Biomol. NMR . 23 (2): 165–6. doi :10.1023/A:1016363414644 . PMID 12153047 . S2CID 30891765 .
Chen L, Segal D, Hukriede NA, et al. (2002). "Ssdp proteins interact with the LIM-domain-binding protein Ldb1 to regulate development" . Proc. Natl. Acad. Sci. U.S.A . 99 (22): 14320–5. Bibcode :2002PNAS...9914320C . doi :10.1073/pnas.212532399 . PMC 137882 . PMID 12381786 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
van Meyel DJ, Thomas JB, Agulnick AD (2003). "Ssdp proteins bind to LIM-interacting co-factors and regulate the activity of LIM-homeodomain protein complexes in vivo". Development . 130 (9): 1915–25. doi :10.1242/dev.00389 . PMID 12642495 . S2CID 6211268 .
Deane JE, Mackay JP, Kwan AH, et al. (2003). "Structural basis for the recognition of ldb1 by the N-terminal LIM domains of LMO2 and LMO4" . EMBO J . 22 (9): 2224–33. doi :10.1093/emboj/cdg196 . PMC 156068 . PMID 12727888 .
Marini M, Bongers EM, Cusano R, et al. (2004). "Confirmation of CLIM2/LMX1B interaction by yeast two-hybrid screening and analysis of its involvement in nail-patella syndrome". Int. J. Mol. Med . 12 (1): 79–82. doi :10.3892/ijmm.12.1.79 . PMID 12792813 .