Protein-coding gene in the species Homo sapiens
KCNN4 Identifiers Aliases KCNN4 , IK1, IKCA1, KCA4, KCa3.1, SK4, hIKCa1, hKCa4, hSK4, IK, DHS2, potassium calcium-activated channel subfamily N member 4External IDs OMIM : 602754 ; MGI : 1277957 ; HomoloGene : 1696 ; GeneCards : KCNN4 ; OMA :KCNN4 - orthologs Wikidata
Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 , also known as KCNN4 , is a human gene encoding the KCa 3.1 protein .[5]
The KCa 3.1 protein is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium . Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes . This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily.[5]
The channel activity was first described in 1958 by György Gárdos in human erythrocytes .[6] The channel is also named Gardos channel because of its discoverer.
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Ghanshani S, Wulff H, Miller MJ, Rohm H, Neben A, Gutman GA, Cahalan MD, Chandy KG (2000). "Up-regulation of the IKCa1 potassium channel during T-cell activation. Molecular mechanism and functional consequences" . J. Biol. Chem . 275 (47): 37137–49. doi :10.1074/jbc.M003941200 . PMID 10961988 .
Wulff H, Miller MJ, Hansel W, Grissmer S, Cahalan MD, Chandy KG (2000). "Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: a potential immunosuppressant" . Proc. Natl. Acad. Sci. U.S.A . 97 (14): 8151–6. Bibcode :2000PNAS...97.8151W . doi :10.1073/pnas.97.14.8151 . PMC 16685 . PMID 10884437 .
Wulff H, Gutman GA, Cahalan MD, Chandy KG (2001). "Delineation of the clotrimazole/TRAM-34 binding site on the intermediate conductance calcium-activated potassium channel, IKCa1" . J. Biol. Chem . 276 (34): 32040–5. doi :10.1074/jbc.M105231200 . PMID 11425865 .
Koegel H, Kaesler S, Burgstahler R, Werner S, Alzheimer C (2003). "Unexpected down-regulation of the hIK1 Ca2+-activated K+ channel by its opener 1-ethyl-2-benzimidazolinone in HaCaT keratinocytes. Inverse effects on cell growth and proliferation" . J. Biol. Chem . 278 (5): 3323–30. doi :10.1074/jbc.M208914200 . PMID 12421833 .
Mazzone JN, Kaiser RA, Buxton IL (2002). "Calcium-activated potassium channel expression in human myometrium: effect of pregnancy". Proc. West. Pharmacol. Soc . 45 : 184–6. PMID 12434576 .
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Mall M, Gonska T, Thomas J, Schreiber R, Seydewitz HH, Kuehr J, Brandis M, Kunzelmann K (2003). "Modulation of Ca2+-activated Cl- secretion by basolateral K+ channels in human normal and cystic fibrosis airway epithelia" . Pediatr. Res . 53 (4): 608–18. doi :10.1203/01.PDR.0000057204.51420.DC . PMID 12612194 .
Hoffman JF, Joiner W, Nehrke K, Potapova O, Foye K, Wickrema A (2003). "The hSK4 (KCNN4) isoform is the Ca2+-activated K+ channel (Gardos channel) in human red blood cells" . Proc. Natl. Acad. Sci. U.S.A . 100 (12): 7366–71. Bibcode :2003PNAS..100.7366H . doi :10.1073/pnas.1232342100 . PMC 165881 . PMID 12773623 .
Bernard K, Bogliolo S, Soriani O, Ehrenfeld J (2003). "Modulation of calcium-dependent chloride secretion by basolateral SK4-like channels in a human bronchial cell line". J. Membr. Biol . 196 (1): 15–31. doi :10.1007/s00232-003-0621-3 . PMID 14724753 . S2CID 20530729 .
Köhler R, Wulff H, Eichler I, Kneifel M, Neumann D, Knorr A, Grgic I, Kämpfe D, Si H, Wibawa J, Real R, Borner K, Brakemeier S, Orzechowski HD, Reusch HP, Paul M, Chandy KG, Hoyer J (2003). "Blockade of the intermediate-conductance calcium-activated potassium channel as a new therapeutic strategy for restenosis" . Circulation . 108 (9): 1119–25. doi :10.1161/01.CIR.0000086464.04719.DD . PMID 12939222 .
Toyama K, Wulff H, Chandy KG, Azam P, Raman G, Saito T, Fujiwara Y, Mattson DL, Das S, Melvin JE, Pratt PF, Hatoum OA, Gutterman DD, Harder DR, Miura H (2008). "The intermediate-conductance calcium-activated potassium channel KCa3.1 contributes to atherogenesis in mice and humans" . J. Clin. Invest . 118 (9): 3025–37. doi :10.1172/JCI30836 . PMC 2496961 . PMID 18688283 .
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Gibson JS, Muzyamba MC (2004). "Modulation of Gardos channel activity by oxidants and oxygen tension: effects of 1-chloro-2,4-dinitrobenzene and phenazine methosulphate". Bioelectrochemistry . 62 (2): 147–52. doi :10.1016/j.bioelechem.2003.07.008 . PMID 15039018 .
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This article incorporates text from the United States National Library of Medicine , which is in the public domain .