First contact may refer to:

• First contact (astronomy), the moment in astronomical transit when the apparent positions of the two bodies first touch
• First contact (anthropology), the first meeting of two cultures previously unaware of one another
• First contact (science fiction), a common science fiction theme about the first meeting between humans and extraterrestrial life

• Star Trek: First Contact, a 1996 film in the Star Trek science fiction franchise
• First Contact (1983 film), a 1983 documentary by Bob Connolly and Robin Anderson
• Ultraman Cosmos: The First Contact, a 2001 theatrical film adaptation of the Ultraman Cosmos TV series

• First Contact (Australian TV series), a 2014 Australian television documentary
• First Contact (Canadian TV series), a 2018 Canadian documentary television series

• "First Contact" (Star Trek: The Next Generation), a 1991 episode of the science fiction television series Star Trek: The Next Generation
• "First Contact", the 1994 pilot episode of Earth 2 TV series
• "First Contact" (Stargate Atlantis), a 2008 episode of Stargate Atlantis
• "First Con-tact" (Star Trek: Prodigy), a 2022 episode of Star Trek: Prodigy
• "Episode 0: First Contact", one of the television specials in the Lupin III Japanese media franchise

• First Contact (novelette), a 1945 science fiction novelette by Murray Leinster
• First Contact?, a 1971 science fiction novel by Hugh Walters
• First Contact, a 2004 book by Mark Anstice
• First Contact: Or, It's Later Than You Think, a 2010 satire book by Evan Mandery

• First Contact (Roger Sanchez album), 2001
• First Contact (Lastlings album), 2020

• All pages with titles containing First contact
• Potential cultural impact of extraterrestrial contact