Protein-coding gene in the species Homo sapiens
Protocadherin Fat 4 , also known as cadherin family member 14 (CDHF14) or FAT tumor suppressor homolog 4 (FAT4), is a protein that in humans is encoded by the FAT4 gene .[5] [6]
FAT4 is associated with the Hippo signaling pathway .[7]
Clinical significance [ edit ]
Mutations in FAT4 are associated to Hennekam syndrome .[8]
^ a b c GRCh38: Ensembl release 89: ENSG00000196159 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000046743 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
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^ Höng JC, Ivanov NV, Hodor P, Xia M, Wei N, Blevins R, Gerhold D, Borodovsky M, Liu Y (March 2004). "Identification of new human cadherin genes using a combination of protein motif search and gene finding methods". J. Mol. Biol . 337 (2): 307–17. doi :10.1016/j.jmb.2004.01.026 . PMID 15003449 .
^ Qi C, Zhu YT, Hu L, Zhu YJ (February 2009). "Identification of Fat4 as a candidate tumor suppressor gene in breast cancers" . Int. J. Cancer . 124 (4): 793–8. doi :10.1002/ijc.23775 . PMC 2667156 . PMID 19048595 .
^ Alders, M; Al-Gazali, L; Cordeiro, I; Dallapiccola, B; Garavelli, L; Tuysuz, B; Salehi, F; Haagmans, M. A.; Mook, O. R.; Majoie, C. B.; Mannens, M. M.; Hennekam, R. C. (2014). "Hennekam syndrome can be caused by FAT4 mutations and be allelic to Van Maldergem syndrome". Human Genetics . 133 (9): 1161–1167. doi :10.1007/s00439-014-1456-y . PMID 24913602 . S2CID 14414158 .
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