Diego is a Spanish male name.

Diego may also refer to:

• Diego (given name), including a list of people with the given name
• Diego (surname), including a list of people with the surname

• Go, Diego, Go!, a US children's television show
• Diego (band), an indie rock band from Germany
• Diego (Ice Age), a Smilodon from the children's animated movie franchise Ice Age
• Diego (album), a 2005 album by Diego Boneta

• DIEGO (furniture store), a Hungary-based retail furniture chain
• Diego (grape) or Vigiriega, a Spanish grape
• Diego (tortoise), a Hood Island giant tortoise
• Diego antigen system, a system of blood groups
• Diego's Hair Salon, in Washington, D.C.
• Winter Storm Diego, a December 2018 storm in the United States

• San Diego (disambiguation)