David Johnston or Dave Johnston may refer to:

• David Johnston (governor general) (born 1941), former governor general of Canada
• David Johnston (Australian politician) (born 1956), Australian Senator and former Defence Minister
• David Johnston (British politician) (born 1981), British politician
• David Emmons Johnston (1845–1917), U.S. Congressman
• David Russell Johnston (1932–2008), Scottish politician

• David Johnston (Australian footballer) (born 1969), former Australian rules footballer
• Davie Johnston (footballer, born 1942) (1942–2004), Scottish footballer, played for Heart of Midlothian FC and Aberdeen FC
• Davie Johnston (footballer, born 1948), Scottish footballer, played for Dundee FC
• David Johnston (rugby union, born 1958), Scottish rugby player and coach, also played football for Heart of Midlothian FC
• David Johnston (English cricketer) (born 1943), former English cricketer
• David Johnston (South Australia cricketer) (born 1954), Australian cricketer
• David Johnston (New South Wales cricketer) (born 1955), Australian cricketer
• David Johnston (rugby union, born 1994), Irish rugby player
• D. T. Johnston (1889–1953), Australian sportsman and local politician

• David Johnston (minister) (1734-1824) Church of Scotland minister of Leith
• Dave Johnston (musician), American banjo player for Yonder Mountain String Band
• Dave Johnston (police officer), head of the Homicide and Serious Crime Command for the Metropolitan Police (United Kingdom)
• David Johnston (newsreader) (born 1941), former Australian newsreader
• David A. Johnston (1949–1980), volcanologist killed in the 1980 eruption of Mount St. Helens
• David Cay Johnston (born 1948), investigative journalist
• David Claypoole Johnston (1799–1865), American cartoonist, printmaker, painter and actor
• David E. Johnston, British classical archaeologist and historian
• David Johnston (admiral) (born 1962), senior officer in the Royal Australian Navy
• David Eric Lothian Johnston (born 1961), Scottish legal expert
• David Johnston (merchant) (1724–1809), American merchant and politician
• David Jhave Johnston, Canadian poet, videographer, and motion graphics artist
• David Johnston (soldier) (1838-1931) American soldier and recipient of the Medal of Honor

• David Johnson (disambiguation)