Protein-coding gene in the species Homo sapiens
Centrosomal protein of 164 kDa , also known as CEP164 , is a protein that in humans is encoded by the CEP164 gene .[5] [6]
Its function appears two be twofold: CEP164 is required for primary cilium formation.[7] Furthermore, it is an important component in the response to DNA damage by UV light .[8] [9]
References [ edit ]
^ a b c GRCh38: Ensembl release 89: ENSG00000110274 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000043987 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Entrez Gene: centrosomal protein 164kDa" .
^ Andersen JS, Wilkinson CJ, Mayor T, Mortensen P, Nigg EA, Mann M (December 2003). "Proteomic characterization of the human centrosome by protein correlation profiling". Nature . 426 (6966): 570–4. Bibcode :2003Natur.426..570A . doi :10.1038/nature02166 . PMID 14654843 . S2CID 4427303 .
^ Graser, S.; Stierhof, Y. -D.; Lavoie, S. B.; Gassner, O. S.; Lamla, S.; Le Clech, M.; Nigg, E. A. (2007). "Cep164, a novel centriole appendage protein required for primary cilium formation" . The Journal of Cell Biology . 179 (2): 321–30. doi :10.1083/jcb.200707181 . PMC 2064767 . PMID 17954613 .
^ Sivasubramaniam, S.; Sun, X.; Pan, Y. -R.; Wang, S.; Lee, E. Y. -H. P. (2008). "Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1" . Genes & Development . 22 (5): 587–600. doi :10.1101/gad.1627708 . PMC 2259029 . PMID 18283122 .
^ Pan, YR; Lee, EY (2009). "UV-dependent interaction between Cep164 and XPA mediates localization of Cep164 at sites of DNA damage and UV sensitivity" . Cell Cycle . 8 (4): 655–64. doi :10.4161/cc.8.4.7844 . PMID 19197159 .
External links [ edit ]
Further reading [ edit ]
Graser S, Stierhof YD, Lavoie SB, et al. (2007). "Cep164, a novel centriole appendage protein required for primary cilium formation" . J. Cell Biol . 179 (2): 321–30. doi :10.1083/jcb.200707181 . PMC 2064767 . PMID 17954613 .
Golsteyn RM, Mundt KE, Fry AM, Nigg EA (1995). "Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function" . J. Cell Biol . 129 (6): 1617–28. doi :10.1083/jcb.129.6.1617 . PMC 2291169 . PMID 7790358 .
Casenghi M, Meraldi P, Weinhart U, et al. (2003). "Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation" . Dev. Cell . 5 (1): 113–25. doi :10.1016/S1534-5807(03)00193-X . PMID 12852856 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 . PMID 14702039 .
Mayor T, Stierhof YD, Tanaka K, et al. (2000). "The Centrosomal Protein C-Nap1 Is Required for Cell Cycle–Regulated Centrosome Cohesion" . J. Cell Biol . 151 (4): 837–46. doi :10.1083/jcb.151.4.837 . PMC 2169446 . PMID 11076968 .
Sivasubramaniam S, Sun X, Pan YR, et al. (2008). "Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1" . Genes Dev . 22 (5): 587–600. doi :10.1101/gad.1627708 . PMC 2259029 . PMID 18283122 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Petretti C, Savoian M, Montembault E, et al. (2006). "The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation" . EMBO Rep . 7 (4): 418–24. doi :10.1038/sj.embor.7400639 . PMC 1456919 . PMID 16462731 .
Zick A, Onn I, Bezalel R, et al. (2005). "Assigning functions to genes: identification of S-phase expressed genes in Leishmania major based on post-transcriptional control elements" . Nucleic Acids Res . 33 (13): 4235–42. doi :10.1093/nar/gki742 . PMC 1181863 . PMID 16052032 .
Pan YR, Lee EY (2009). "UV-dependent interaction between Cep164 and XPA mediates localization of Cep164 at sites of DNA damage and UV sensitivity" . Cell Cycle . 8 (4): 655–64. doi :10.4161/cc.8.4.7844 . PMID 19197159 .
Takahashi M, Yamagiwa A, Nishimura T, et al. (2002). "Centrosomal Proteins CG-NAP and Kendrin Provide Microtubule Nucleation Sites by Anchoring γ-Tubulin Ring Complex" . Mol. Biol. Cell . 13 (9): 3235–45. doi :10.1091/mbc.E02-02-0112 . PMC 124155 . PMID 12221128 .