Microtubule minus-end binding human protein
Calmodulin-regulated spectrin-associated protein 1 (CAMSAP1) is a human protein encoded by the gene CAMSAP1. Like other CAMSAP-family proteins, it is a microtubule minus-end anchor, and binds microtubules through its CKK domain .[4]
Clinical significance [ edit ] CAMSAP1 is vital for neuron polarisation, and so mice that lack CAMSAP1 die of epileptic seizures .[5]
See also [ edit ] References [ edit ]
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026933 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Baines, A. J.; Bignone, P. A.; King, M. D.A.; Maggs, A. M.; Bennett, P. M.; Pinder, J. C.; Phillips, G. W. (2009-09-01). "The CKK Domain (DUF1781) Binds Microtubules and Defines the CAMSAP/ssp4 Family of Animal Proteins" . Molecular Biology and Evolution . 26 (9): 2005–2014. doi :10.1093/molbev/msp115 ISSN 0737-4038 . PMID 19508979 . ^ Zhou Z, Xu H, Li Y, Yang M, Zhang R, Shiraishi A, et al. (September 2020). "CAMSAP1 breaks the homeostatic microtubule network to instruct neuronal polarity" . Proceedings of the National Academy of Sciences of the United States of America . 117 (36): 22193–22203. Bibcode :2020PNAS..11722193Z . doi :10.1073/pnas.1913177117 PMC 7486724 PMID 32839317 .
