Brca or BRCA may refer to:

• Brca (Bar Municipality), a village in Macedonia
• BRCA mutation, mutations in two genes which produce a hereditary breast-ovarian cancer syndrome
  • BRCA1, the first of these genes to be discovered
  • BRCA2, the second of these genes to be discovered
• British Radio Car Association, a British radio controlled car racing organisation
• Brotherhood Railway Carmen of America, a defunct American trade union
• Bureau Central de Renseignements et d'Action, the Free French intelligence agency during World War II