Andy or Andrew O'Brien may refer to:

• Andy O'Brien (footballer) (born 1979), Irish footballer
• Andy O'Brien (hurler) (born 1988), Irish hurler
• Andy O'Brien (journalist) (1910–1987), Canadian sports journalist
• Andy O'Brien (politician) (1915–2006), Irish Fine Gael senator
• Andrew O'Brien (politician) (fl. 1990s-2010s), US Department of State official
• Andrew O'Brien (rugby) (1897–1969), New Zealand rugby footballer

Fictional[edit]

• Andy O'Brien (EastEnders), a character in EastEnders