Protein-coding gene in humans
Zinc finger homeobox protein 3 is a protein that in humans is encoded by the ZFHX3 gene .[ 5] [ 6] [ 7]
^ a b c GRCh38: Ensembl release 89: ENSG00000140836 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038872 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Morinaga T, Yasuda H, Hashimoto T, Higashio K, Tamaoki T (Dec 1991). "A human alpha-fetoprotein enhancer-binding protein, ATBF1, contains four homeodomains and seventeen zinc fingers" . Mol Cell Biol . 11 (12): 6041–9. doi :10.1128/MCB.11.12.6041 . PMC 361769 . PMID 1719379 .
^ Miura Y, Tam T, Ido A, Morinaga T, Miki T, Hashimoto T, Tamaoki T (Dec 1995). "Cloning and characterization of an ATBF1 isoform that expresses in a neuronal differentiation-dependent manner" . J Biol Chem . 270 (45): 26840–8. doi :10.1074/jbc.270.45.26840 . PMID 7592926 .
^ "Entrez Gene: ATBF1 AT-binding transcription factor 1" .
Yamada K, Miura Y, Scheidl T, et al. (1996). "Assignment of the human ATBF1 transcription factor gene to chromosome 16q22.3-q23.1". Genomics . 29 (2): 552–3. doi :10.1006/geno.1995.9967 . PMID 8666409 .
Bedford MT, Chan DC, Leder P (1997). "FBP WW domains and the Abl SH3 domain bind to a specific class of proline-rich ligands" . EMBO J . 16 (9): 2376–83. doi :10.1093/emboj/16.9.2376 . PMC 1169838 . PMID 9171351 .
Kaspar P, Dvoráková M, Králová J, et al. (1999). "Myb-interacting protein, ATBF1, represses transcriptional activity of Myb oncoprotein" . J. Biol. Chem . 274 (20): 14422–8. doi :10.1074/jbc.274.20.14422 . PMID 10318867 .
Loftus BJ, Kim UJ, Sneddon VP, et al. (1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics . 60 (3): 295–308. doi :10.1006/geno.1999.5927 . PMID 10493829 .
Kaushik N, Malaspina A, de Belleroche J (2000). "Characterization of trinucleotide- and tandem repeat-containing transcripts obtained from human spinal cord cDNA library by high-density filter hybridization". DNA Cell Biol . 19 (5): 265–73. doi :10.1089/10445490050021177 . PMID 10855793 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Iida M, Imura J, Furuichi T, et al. (2004). "Alteration of the AT motif binding factor-1 expression in alpha-fetoprotein producing gastric cancer: is it an event for differentiation and proliferation of the tumors?". Oncol. Rep . 11 (1): 3–7. doi :10.3892/or.11.1.3 . PMID 14654895 .
Nojiri S, Joh T, Miura Y, et al. (2004). "ATBF1 enhances the suppression of STAT3 signaling by interaction with PIAS3". Biochem. Biophys. Res. Commun . 314 (1): 97–103. doi :10.1016/j.bbrc.2003.12.054 . PMID 14715251 .
Martin J, Han C, Gordon LA, et al. (2005). "The sequence and analysis of duplication-rich human chromosome 16" . Nature . 432 (7020): 988–94. Bibcode :2004Natur.432..988M . doi :10.1038/nature03187 . PMID 15616553 .
Zhang Z, Yamashita H, Toyama T, et al. (2005). "ATBF1-a messenger RNA expression is correlated with better prognosis in breast cancer" . Clin. Cancer Res . 11 (1): 193–8. doi :10.1158/1078-0432.193.11.1 . PMID 15671546 .
Sun X, Frierson HF, Chen C, et al. (2005). "Frequent somatic mutations of the transcription factor ATBF1 in human prostate cancer". Nat. Genet . 37 (4): 407–12. doi :10.1038/ng1528 . PMID 15750593 . S2CID 19458711 .
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 .
Xu J, Sauvageot J, Ewing CM, et al. (2006). "Germline ATBF1 mutations and prostate cancer risk" . Prostate . 66 (10): 1082–5. doi :10.1002/pros.20430 . PMID 16637072 . S2CID 21238472 .
Sun X, Zhou Y, Otto KB, et al. (2007). "Infrequent mutation of ATBF1 in human breast cancer". J. Cancer Res. Clin. Oncol . 133 (2): 103–5. doi :10.1007/s00432-006-0148-y . PMID 16932943 . S2CID 12378418 .
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635–48. doi :10.1016/j.cell.2006.09.026 . PMID 17081983 . S2CID 7827573 .
Mori Y, Kataoka H, Miura Y, et al. (2007). "Subcellular localization of ATBF1 regulates MUC5AC transcription in gastric cancer" . Int. J. Cancer . 121 (2): 241–7. doi :10.1002/ijc.22654 . PMID 17330845 . S2CID 37176312 .
Cho YG, Song JH, Kim CJ, et al. (2007). "Genetic alterations of the ATBF1 gene in gastric cancer" . Clin. Cancer Res . 13 (15 Pt 1): 4355–9. doi :10.1158/1078-0432.CCR-07-0619 . PMID 17671116 .
PDB gallery
2da1 : Solution structure of the first homeobox domain of AT-binding transcription factor 1 (ATBF1)
2da2 : Solution structure of the second homeobox domain of AT-binding transcription factor 1 (ATBF1)
2da3 : Solution structure of the third homeobox domain of AT-binding transcription factor 1 (ATBF1)
(1) Basic domains
(1.1) Basic leucine zipper (bZIP )(1.2) Basic helix-loop-helix (bHLH )
Group A Group B Group C bHLH-PAS Group D Group E Group F bHLH-COE
(1.3) bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4 )
subfamily 1 subfamily 2 subfamily 3 subfamily 4 subfamily 5 subfamily 6 subfamily 0
(2.2) Other Cys4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) Alternating composition (2.6) WRKY
(4) β-Scaffold factors with minor groove contacts
(0) Other transcription factors