These are the squads for the countries that played in the 1921 South American Championship. The participating countries were Argentina, Brazil, Chile and Uruguay. The teams plays in a single round-robin tournament, earning two points for a win, one point for a draw, and zero points for a loss.^[1][2]

Head Coach: n/i ^{[note 1]}

No.	Pos.	Player	Date of birth (age)	Caps	Goals	Club
—	2DF	Florindo Bearzotti		0	0	Belgrano (Rosario)
—	4FW	Pedro Calomino	(1892-03-13)13 March 1892 (aged 28)	0	0	Boca Juniors
—	2DF	Adolfo Celli		0	0	Newell's Old Boys
—	4FW	Jaime Chavín		0	0	Huracán
—	3MF	Miguel Dellavalle		0	0	Belgrano (C)
—	4FW	Raúl Echeverría		0	0	Estudiantes (LP)
—	3MF	Alfredo Elli		0	0	Boca Juniors
—	4FW	Vicente González		0	0	Gimnasia y Esgrima (Mza)
—	4FW	Julio Libonatti		0	0	Newell's Old Boys
—	3MF	José Alfredo López		0	0	Boca Juniors
—	1GK	Ernesto Kiesel		0	0	Huracán
—	2DF	Juan Salvador Geronimo Presta		0	0	Porteño
—	4FW	Blas Saruppo		0	0	Newell's Old Boys
—	3MF	Emilio Solari		0	0	Nueva Chicago
—	3MF	Gabino Sosa		0	0	Central Córdoba (R)
—	1GK	Américo Tesoriere		0	0	Boca Juniors

Head coach: Ferreira Vianna Netto

No.	Pos.	Player	Date of birth (age)	Caps	Goals	Club
—	4FW	Alfredinho		0	0	Botafogo
—	2DF	Barata		0	0	America
—	4FW	Candiota		0	0	Flamengo
—	2DF	Caratório		0	0	Andaraí
—	1GK	Carnaval		0	0	São Cristóvão
—	3MF	Dino		0	0	Flamengo
—	4FW	Fréderico		0	0	Bangu
—	1GK	Kuntz	(1897-09-03)3 September 1897 (aged 25)	0	0	Flamengo
—	3MF	Laís		0	0	Fluminense
—	4FW	Machado		0	0	Fluminense
—	3MF	Maxambomba		0	0	Coritiba
—	4FW	Nono		0	0	Flamengo
—	4FW	Paulo Sampaio Vianna		0	0	Fluminense
—	3MF	Pena		0	0	Coritiba
—	4FW	Orlandinho		0	0	Flamengo
—	2DF	Telefone		0	0	Flamengo
—	4FW	Zezé		0	0	Fluminense

Head Coach: José Durand Laguna

No.	Pos.	Player	Date of birth (age)	Caps	Goals	Club
—	1GK	Manuel Radice [pl]		0	0
—	1GK	Ángel Portaluppi [pl]	(1898-04-14)14 April 1898 (aged 23)	0	0
—	2DF	Ramón González [pl]		0	0
—	2DF	Venancio Paredes [pl]		0	0
—	3MF	Isidoro Benítez Casco [pl]		0	0
—	3MF	Manuel Fleitas Solich	(1900-12-30)30 December 1900 (aged 20)	0	0	Nacional
—	3MF	Arsenio Rodríguez [pl]		0	0
—	4FW	Alejandro Delgado [pl]		0	0
—	4FW	Darío Lima [pl]		0	0
—	4FW	Ildefonso López [pl]		0	0
—	4FW	Gerardo Rivas [pl]		0	0	Libertad
—	4FW	Daniel Schaerer [pl]		0	0
—	4FW	Francisco Vera [pl]		0	0
—	4FW	Agustín Zelada [pl]		0	0

Head Coach: Ernesto Fígoli

No.	Pos.	Player	Date of birth (age)	Caps	Goals	Club
—	1GK	Manuel Beloutas		0	0	Universal
—	2DF	José Pedro Benincasa		0	0	Peñarol
—	3MF	Oscar Bianchi		0	0	Charley [es]
—	3MF	Fausto Broncini		0	0	Central
—	4FW	Antonio Campolo		0	0	Peñarol
—	4FW	Norberto Casanello		0	0	Wanderers
—	1GK	Pedro Casella		0	0	Belgrano
—	2DF	Alfredo Foglino		0	0	Nacional
—	2DF	Marcelo Lietti		0	0	Universal
—	3MF	Sebastián Marroche		0	0	Nacional
—	2DF	Juan Molinari		0	0	Universal
—	4FW	Ladislao Pérez		0	0	Universal
—	4FW	José Piendibene		0	0	Peñarol
—	4FW	Ángel Romano		0	0	Nacional
—	2DF	Esteban Ruibal		0	0	Central
—	4FW	Pascual Somma		0	0	Nacional
—	3MF	Luis Villazú		0	0	Lito [es]
—	3MF	Alfredo Zibechi		0	0	Nacional