Events from the year 1512 in art.

• Michelangelo completes his nine Sistine Chapel ceiling paintings of the Creation.

• Hans Baldung – The Trinity and Mystic Pietà
• Fra Bartolomeo – Madonna in Glory with Saints (altarpiece, Besançon Cathedral, 1511–12)
• Albrecht Dürer – The Virgin Mary Appearing to St. John on Patmos (woodcut)
• Leonardo da Vinci – Self-portrait in red chalk (approximate date)
• Michelangelo – Sistine Chapel ceiling, including the Separation of Light from Darkness (completed)
• Raphael
  • The Expulsion of Heliodorus from the Temple (fresco in the Raphael Rooms of the Apostolic Palace in the Vatican)
  • Portrait of Pope Julius II
  • The Triumph of Galatea (fresco in Villa Farnesina in Rome)
• Titian – approximate date
  • The Gypsy Madonna
  • La Schiavona
  • The Three Ages of Man
• Lucas van Leyden – The History of Joseph series of engravings, e.g. Joseph Explains Pharaoh's Dream
• Bernard van Orley – Triptych of the Carpenters and Masons Corporation of Brussels ("Apostle Altar")

• date unknown
  • Lazzaro Calvi, Italian painter who frequently collaborated with his brother (died 1587)
  • Luis de Morales, Spanish painter known as "El Divino" (died 1586)
  • Battista del Moro, Italian painter of the Renaissance period active in his native Verona (died 1568)
  • Prospero Fontana, Italian painter of the late Renaissance, (died 1597)
• (born 1512/1520): Giorgio Ghisi, Italian coppersmith, painter, and engraver (died 1582)
• 1512/1515: Marcello Venusti, Italian Mannerist painter primarily in Rome (died 1579)

• April 5 - Lazzaro Bastiani, Italian painter of the Renaissance, active mainly in Venice (born 1449)
• date unknown - Giovanni Cristoforo Romano, Italian sculptor and medallist (born 1456)