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Fernandez held the Karl F. Hasselmann Professorship of Bioengineering at [[Rice University]] until 2011.<ref>{{citation|contribution-url=http://www.rice.edu/catalog/2010_2011/PDF/09_AdministrationFaculty.pdf|contribution=Administration and faculty|url=http://www.rice.edu/catalog/2010_2011/|title=Catalog 2010–2011|publisher=Rice University|accessdate=December 2, 2014|archive-url=https://web.archive.org/web/20141125102257/http://www.rice.edu/catalog/2010_2011/|archive-date=November 25, 2014|url-status=dead}}.</ref> He is a member of the [[National Scientific and Technical Research Council]] (CONICET) in Argentina.<ref>{{cite web|url=http://www.conicet.gov.ar/new_scp/detalle.php?keywords=&id=33676&datos_academicos=yes|title=Comunicación - Conicet|work=CONICET}}</ref> He does [[biotechnology consulting]] and has been involved with [[startup company|startups]].<ref name="CV" />
Fernandez held the Karl F. Hasselmann Professorship of Bioengineering at [[Rice University]] until 2011.<ref>{{citation|contribution-url=http://www.rice.edu/catalog/2010_2011/PDF/09_AdministrationFaculty.pdf|contribution=Administration and faculty|url=http://www.rice.edu/catalog/2010_2011/|title=Catalog 2010–2011|publisher=Rice University|accessdate=December 2, 2014|archive-url=https://web.archive.org/web/20141125102257/http://www.rice.edu/catalog/2010_2011/|archive-date=November 25, 2014|url-status=dead}}.</ref> He is a member of the [[National Scientific and Technical Research Council]] (CONICET) in Argentina.<ref>{{cite web|url=http://www.conicet.gov.ar/new_scp/detalle.php?keywords=&id=33676&datos_academicos=yes|title=Comunicación - Conicet|work=CONICET}}</ref> He does [[biotechnology consulting]] and has been involved with [[startup company|startups]].<ref name="CV" />


Fernandez developed the concept of the [[dehydron]], an adhesive structural defect in a soluble [[protein]] that promotes its own dehydration.<ref>{{cite journal |journal=[[Physics (magazine)|Physics]] |last=Monroe |first=Dan |title=Proteins Hook up Where Water Allows |year=2012 |volume=5 |issue=51 |page=51 |doi=10.1103/Physics.5.51 |bibcode=2012PhyOJ...5...51M |url=http://physics.aps.org/articles/v5/51 |accessdate=June 23, 2021}}</ref> The nonconserved nature of protein dehydrons has implications for [[drug discovery]], as dehydrons may be targeted by highly specific drugs/ligands.<ref>{{cite journal |last=Crunkhorn |first=Sarah |title=Anticancer drugs: Redesigning kinase inhibitors |year=2008 |journal=[[Nature Reviews Drug Discovery]] |volume=7 |pages=120–121 |doi=10.1038/nrd2524 |s2cid=27083179 |url=http://www.nature.com/nrd/journal/v7/n2/full/nrd2524.html}}</ref> This technology was applied by Fernandez and collaborators to design a new compound based on the anticancer drug [[Gleevec]], in order to remove its potential [[cardiotoxicity]].<ref>Demetri G. D. Structural reengineering of imatinib to decrease cardiac risk in cancer therapy.2007 Dec 3; J Clin Invest. 117(12):3650–3653. doi 10.1172/JCI34252 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2096446/]</ref><ref>Dunham W. Reworked Gleevec curbs heart-related complication. REUTERS December 3, 2007 [https://www.reuters.com/article/us-cancer-gleevec-idUSN0341290220071203]</ref>
Fernandez developed the concept of the [[dehydron]], an adhesive structural defect in a soluble [[protein]] that promotes its own dehydration.<ref>{{cite journal |journal=[[Physics (magazine)|Physics]] |last=Monroe |first=Dan |title=Proteins Hook up Where Water Allows |year=2012 |volume=5 |issue=51 |page=51 |doi=10.1103/Physics.5.51 |bibcode=2012PhyOJ...5...51M |url=http://physics.aps.org/articles/v5/51 |accessdate=June 23, 2021}}</ref> The nonconserved nature of protein dehydrons has implications for [[drug discovery]], as dehydrons may be targeted by highly specific drugs/ligands.<ref>{{cite journal |last=Crunkhorn |first=Sarah |title=Anticancer drugs: Redesigning kinase inhibitors |year=2008 |journal=[[Nature Reviews Drug Discovery]] |volume=7 |pages=120–121 |doi=10.1038/nrd2524 |s2cid=27083179 |url=http://www.nature.com/nrd/journal/v7/n2/full/nrd2524.html}}</ref> This technology was applied by Fernandez and collaborators to design a new compound based on the anticancer drug [[Gleevec]], in order to remove its potential [[cardiotoxicity]].<ref>Demetri G. D. Structural reengineering of imatinib to decrease cardiac risk in cancer therapy.2007 Dec 3; J Clin Invest. 117(12):3650–3653. doi 10.1172/JCI34252 [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2096446/]</ref><ref>Dunham W. Reworked Gleevec curbs heart-related complication. REUTERS December 3, 2007 [https://www.reuters.com/article/us-cancer-gleevec-idUSN0341290220071203]</ref>

Due to apparent problems with the reported data, three of Fernandez's research articles have received Expressions of Concern from the publishing journals; specifically, articles published in ''[[BMC Genomics]]'',<ref>{{cite journal | last1 = Kowalczuk | first1 = M | last2 = Nanda | first2 = S | last3 = Moylan | first3 = E | title = Expression of concern: Subfunctionalization reduces the fitness cost of gene duplication in humans by buffering dosage imbalances | journal = BMC Genomics | volume = 14 | page = 260 | doi = 10.1186/1471-2164-14-260 | date = Apr 2013 | pmid=23594279 | pmc=3639916}}</ref><ref>{{cite web | last = Marcus | first = Adam | title = 'Conflicting investigations' prompt expression of concern in BMC Genomics | date =April 19, 2013| website=[[Retraction Watch]] | url =http://retractionwatch.com/2013/04/19/conflicting-investigations-prompt-expression-of-concern-in-bmc-genomics/}}</ref> ''[[Nature (journal)|Nature]]'',<ref name="natureEOC">{{cite journal | last1=Fernandez | first1=A | last2=Lynch | first2=M | date = Dec 2014 | title = Editorial Expression of Concern: Non-adaptive origins of interactome complexity | journal = Nature | volume =516 | issue=7531 | page=440 | doi= 10.1038/nature13141 | pmid=25470052 | pmc=4757426| bibcode=2014Natur.516..440F }}</ref><ref>{{cite web | last = Oransky | first = Ivan | title = Nature issues Expression of Concern for paper by author who threatened to sue Retraction Watch | website = [[Retraction Watch]] | date = December 1, 2014| url = http://retractionwatch.com/2014/12/01/nature-issues-expression-of-concern-for-paper-by-author-who-threatened-to-sue-retraction-watch/}}</ref> and ''[[PLOS Genetics]]''.<ref>{{cite journal | last1 = The PLoS Genetics Editors | title = Expression of Concern: Protein Under-Wrapping Causes Dosage Sensitivity and Decreases Gene Duplicability | date = Sep 2015 | doi = 10.1371/journal.pgen.1005499 | pmid = 26367774 | pmc = 4569175 | volume=11 | issue = 9 | journal=PLOS Genetics | page=e1005499}}</ref><ref>{{cite web | last = Palus | first = Shannon | title = PLOS Genetics updates flagged paper with expression of concern | website = [[Retraction Watch]] | date = September 24, 2015| url = http://retractionwatch.com/2015/09/24/plos-genetics-updates-flagged-paper-with-expression-of-concern/}}</ref> A fourth publication associated with ''[[Annual Review of Genetics]]'' has been withheld due to "unsettled anomalies in the data and/or interpretation".<ref>{{cite web | title = Annual Reviews of Genetics – Fernandez | url = http://www.annualreviews.org/page/genet/111212-133310 | website = [[Annual Reviews (publisher)|Annual Reviews]] | access-date = January 5, 2022}}</ref><ref>{{cite web | last = Marcus | first = Adam | title = Fernández genetics paper in limbo over data concerns | website = [[Retraction Watch]] | date = October 24, 2013| url = http://retractionwatch.com/2013/10/24/fernandez-genetics-paper-in-limbo-over-data-concerns/}}</ref> On his personal website Fernandez has disputed that the data in those papers are problematic.<ref>[https://web.archive.org/web/20160124215557/http://www.profarielfernandez.com/disclaimer.html Post on profarielfernandez.com] January 23, 2016.</ref> In 2006, a publication by Fernandez in ''[[Proceedings of the National Academy of Sciences]]'' article was [[retraction|retracted]] as an apparent [[duplicate publication]].<ref>{{cite journal|title=Retraction for Fernández et al., Packing defects as selectivity switches for drug-based protein inhibitors|journal=Proceedings of the National Academy of Sciences|volume=103|issue=11|pages=323–328| doi=10.1073/pnas.0601034103|pmid=16387853|pmc=1326172|year=2006|last1=Cozzarelli|first1=N. R.|last2=Scott|first2=R.|last3=Berry|first3=R. S.|bibcode=2006PNAS..103.4329C|doi-access=free}}</ref><ref>{{cite web | last = Oransky | first = Ivan | title = PLOS Genetics investigating paper by Ariel Fernandez | website = [[Retraction Watch]] | url = http://retractionwatch.com/2015/01/09/plos-genetics-investigating-paper-ariel-fernandez/ | date = January 9, 2015}}</ref>


==Awards==
==Awards==

Revision as of 14:55, 6 January 2022

Ariel Fernandez
Born (1957-04-08) April 8, 1957 (age 67)
Bahía Blanca, Argentina
Citizenship
  • Argentina
  • USA
Alma mater
Known forDehydrons
Scientific career
Fields
Institutions
ThesisStructural Stability of Chemical Systems at Critical Regimes (1984)
Doctoral advisorOktay Sinanoğlu
Websitewww.profarielfernandez.com

Ariel Fernandez (born Ariel Fernández Stigliano, April 8, 1957) is an Argentinian–American physical chemist and pharmaceutical researcher.[1]

Education and early career

Fernandez received Licentiate degrees in Chemistry (1979) and Mathematics (1980) from the Universidad Nacional del Sur, Argentina.[1] He then earned a Ph.D. from Yale University in 1984 with a thesis entitled Structural Stability of Chemical Systems at Critical Regimes[2] in the lab of Oktay Sinanoğlu. His early published papers also list him as being associated with the Weizmann Institute of Science, Princeton University, and the University of California at San Diego. He was a senior researcher in the division of Nobel laureate Manfred Eigen at the Max Planck Institute for Biophysical Chemistry.[1]

Career

Fernandez held the Karl F. Hasselmann Professorship of Bioengineering at Rice University until 2011.[3] He is a member of the National Scientific and Technical Research Council (CONICET) in Argentina.[4] He does biotechnology consulting and has been involved with startups.[1]

Fernandez developed the concept of the dehydron, an adhesive structural defect in a soluble protein that promotes its own dehydration.[5] The nonconserved nature of protein dehydrons has implications for drug discovery, as dehydrons may be targeted by highly specific drugs/ligands.[6] This technology was applied by Fernandez and collaborators to design a new compound based on the anticancer drug Gleevec, in order to remove its potential cardiotoxicity.[7][8]

Due to apparent problems with the reported data, three of Fernandez's research articles have received Expressions of Concern from the publishing journals; specifically, articles published in BMC Genomics,[9][10] Nature,[11][12] and PLOS Genetics.[13][14] A fourth publication associated with Annual Review of Genetics has been withheld due to "unsettled anomalies in the data and/or interpretation".[15][16] On his personal website Fernandez has disputed that the data in those papers are problematic.[17] In 2006, a publication by Fernandez in Proceedings of the National Academy of Sciences article was retracted as an apparent duplicate publication.[18][19]

Awards

Fernandez was awarded the Camille and Henry Dreyfus Distinguished New Faculty in 1989;[1] the Camille and Henry Dreyfus Teacher-Scholar in 1991;[20] a Guggenheim fellowship in 1995;[21] and was an Elected Fellow of the American Institute for Medical and Biological Engineering (2006).[22]

Published books

  • Transformative Concepts for Drug Design: Target Wrapping, by Ariel Fernández (ISBN 978-3642117916, Springer-Verlag, Berlin, Heidelberg, 2010).
  • Biomolecular Interfaces, by Ariel Fernández Stigliano (ISBN 978-3319168494, Springer-Verlag, Berlin, Heidelberg, 2015).
  • Physics at the Biomolecular Interface, by Ariel Fernández (ISBN 978-3319308517, Springer International Publishing AG, Switzerland, 2016).
  • A Mathematical Approach to Protein Biophysics, by L. Ridgeway Scott and Ariel Fernández (ISBN 978-3319660318, Springer, 2017).
  • Artificial Intelligence Platform for Molecular Targeted Therapy: A Translational Science Approach, by Ariel Fernández (ISBN 978-9811232305, World Scientific Publishing Co., 2021).

References

  1. ^ a b c d e Ariel Fernandez. "Ariel Fernandez CV and Biographical Narrative". Academia.edu.
  2. ^ Ariel Fernandez. Yale University Dissertation: Structural Stability of Chemical Systems at Critical Regimes (Dissipative Structures, Potential Energy Surfaces). Published/Created:1984
  3. ^ "Administration and faculty", Catalog 2010–2011, Rice University, archived from the original (PDF) on November 25, 2014, retrieved December 2, 2014.
  4. ^ "Comunicación - Conicet". CONICET.
  5. ^ Monroe, Dan (2012). "Proteins Hook up Where Water Allows". Physics. 5 (51): 51. Bibcode:2012PhyOJ...5...51M. doi:10.1103/Physics.5.51. Retrieved June 23, 2021.
  6. ^ Crunkhorn, Sarah (2008). "Anticancer drugs: Redesigning kinase inhibitors". Nature Reviews Drug Discovery. 7: 120–121. doi:10.1038/nrd2524. S2CID 27083179.
  7. ^ Demetri G. D. Structural reengineering of imatinib to decrease cardiac risk in cancer therapy.2007 Dec 3; J Clin Invest. 117(12):3650–3653. doi 10.1172/JCI34252 [1]
  8. ^ Dunham W. Reworked Gleevec curbs heart-related complication. REUTERS December 3, 2007 [2]
  9. ^ Kowalczuk, M; Nanda, S; Moylan, E (April 2013). "Expression of concern: Subfunctionalization reduces the fitness cost of gene duplication in humans by buffering dosage imbalances". BMC Genomics. 14: 260. doi:10.1186/1471-2164-14-260. PMC 3639916. PMID 23594279.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  10. ^ Marcus, Adam (April 19, 2013). "'Conflicting investigations' prompt expression of concern in BMC Genomics". Retraction Watch.
  11. ^ Fernandez, A; Lynch, M (December 2014). "Editorial Expression of Concern: Non-adaptive origins of interactome complexity". Nature. 516 (7531): 440. Bibcode:2014Natur.516..440F. doi:10.1038/nature13141. PMC 4757426. PMID 25470052.
  12. ^ Oransky, Ivan (December 1, 2014). "Nature issues Expression of Concern for paper by author who threatened to sue Retraction Watch". Retraction Watch.
  13. ^ The PLoS Genetics Editors (September 2015). "Expression of Concern: Protein Under-Wrapping Causes Dosage Sensitivity and Decreases Gene Duplicability". PLOS Genetics. 11 (9): e1005499. doi:10.1371/journal.pgen.1005499. PMC 4569175. PMID 26367774. {{cite journal}}: |last1= has generic name (help)CS1 maint: unflagged free DOI (link)
  14. ^ Palus, Shannon (September 24, 2015). "PLOS Genetics updates flagged paper with expression of concern". Retraction Watch.
  15. ^ "Annual Reviews of Genetics – Fernandez". Annual Reviews. Retrieved January 5, 2022.
  16. ^ Marcus, Adam (October 24, 2013). "Fernández genetics paper in limbo over data concerns". Retraction Watch.
  17. ^ Post on profarielfernandez.com January 23, 2016.
  18. ^ Cozzarelli, N. R.; Scott, R.; Berry, R. S. (2006). "Retraction for Fernández et al., Packing defects as selectivity switches for drug-based protein inhibitors". Proceedings of the National Academy of Sciences. 103 (11): 323–328. Bibcode:2006PNAS..103.4329C. doi:10.1073/pnas.0601034103. PMC 1326172. PMID 16387853.
  19. ^ Oransky, Ivan (January 9, 2015). "PLOS Genetics investigating paper by Ariel Fernandez". Retraction Watch.
  20. ^ "Camille Dreyfus Teacher-Scholar Awards Program Past Awards" (PDF). Archived from the original (PDF) on July 5, 2016. Retrieved December 3, 2014.
  21. ^ "Ariel Fernández". Fellows. John Simon Guggenheim Memorial Foundation. Retrieved September 27, 2012.
  22. ^ "College of Fellows". Members. American Institute for Medical and Biological Engineering. Retrieved September 27, 2012.


source: https://en.wikipedia.org/w/index.php?title=Ariel_Fernandez&diff=1064093879&oldid=1064093728

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