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*[[Mushroom poisoning]] |
*[[Mushroom poisoning]] |
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{{Poisonous Amanitas}} |
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{{Toxins}} |
{{Toxins}} |
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Revision as of 00:30, 19 September 2010
Identifiers | |
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3D model (JSmol)
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CompTox Dashboard (EPA)
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Properties | |
C39H53N9O14S | |
Molar mass | 903.96 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Amanin is a cyclic peptide. It is one of the amatoxins, all of which are found in several members of the Amanita genus of mushrooms.
Toxicology
Like other amatoxins, amanin is an inhibitor of RNA polymerase II. Upon ingestion, it binds to the RNA polymerase II enzyme which completely prevents mRNA synthesis, effectively causing cytolysis of hepatocytes (liver cells) and kidney cells.[1]
References
- ^ M. Cochet-Meillhac and Chambon P. (1974). "Animal DNA-dependent RNA polymerases. 11. Mechanism of the inhibition of RNA polymerases B by amatoxins". Biochim Biophys Acta. 353 (2): 160–184. PMID 4601749.