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{{About|the toxin|the fictional beings with the same name|List of Star Wars races (A-E)#Amanin}} |
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{{Chembox |
{{Chembox |
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| ImageFile = Amanin.png |
| ImageFile = Amanin.png |
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| ImageSize = 200px |
| ImageSize = 200px |
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| IUPACName = |
| IUPACName = |
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| OtherNames = |
| OtherNames = |
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| Section1 = {{Chembox Identifiers |
| Section1 = {{Chembox Identifiers |
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| CASNo = 21150-21-0 |
| CASNo = 21150-21-0 |
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| PubChem = |
| PubChem = |
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| SMILES = O=C(NCC(N[C@@](C(NCC(N[C@@H](C3)C(N[C@@H](CC(O)=O)C(N5[C@H]4C[C@@H](O)C5)=O)=O)=O)=O)([H])[C@@H](C)CC)=O)[C@H](CC1=C(S3=O)NC2=C1C=CC=C2)NC([C@@]([C@@H](C)[C@@H](O)CO)([H])N[C@@]4=O)=O |
| SMILES = O=C(NCC(N[C@@](C(NCC(N[C@@H](C3)C(N[C@@H](CC(O)=O)C(N5[C@H]4C[C@@H](O)C5)=O)=O)=O)=O)([H])[C@@H](C)CC)=O)[C@H](CC1=C(S3=O)NC2=C1C=CC=C2)NC([C@@]([C@@H](C)[C@@H](O)CO)([H])N[C@@]4=O)=O |
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}} |
}} |
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| Section2 = {{Chembox Properties |
| Section2 = {{Chembox Properties |
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| Appearance = |
| Appearance = |
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| C=39 | H=53 | N=9 | O=14 | S=1 |
| C=39 | H=53 | N=9 | O=14 | S=1 |
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| Density = |
| Density = |
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| MeltingPt = |
| MeltingPt = |
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| BoilingPt = |
| BoilingPt = |
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| Solubility = }} |
| Solubility = }} |
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| Section3 = {{Chembox Hazards |
| Section3 = {{Chembox Hazards |
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| MainHazards = |
| MainHazards = |
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| FlashPt = |
| FlashPt = |
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| Autoignition = }} |
| Autoignition = }} |
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'''Amanin''' is a [[Cyclic compound|cyclic]] [[peptide]]. It is one of the [[amatoxin]]s, all of which are found in several members of the ''[[Amanita]]'' genus of [[mushroom]]s. |
'''Amanin''' is a [[Cyclic compound|cyclic]] [[peptide]]. It is one of the [[amatoxin]]s, all of which are found in several members of the ''[[Amanita]]'' genus of [[mushroom]]s. |
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==Toxicology== |
==Toxicology== |
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==References== |
==References== |
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{{Reflist}} |
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==See also== |
==See also== |
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Revision as of 18:41, 16 July 2010
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| Identifiers | |
|---|---|
3D model (JSmol)
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CompTox Dashboard (EPA)
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| Properties | |
| C39H53N9O14S | |
| Molar mass | 903.96 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Amanin is a cyclic peptide. It is one of the amatoxins, all of which are found in several members of the Amanita genus of mushrooms.
Toxicology
Like other amatoxins, amanin is an inhibitor of RNA polymerase II. Upon ingestion, it binds to the RNA polymerase II enzyme which completely prevents mRNA synthesis, effectively causing cytolysis of hepatocytes (liver cells) and kidney cells.[1]
References
- ^ M. Cochet-Meillhac and Chambon P. (1974). "Animal DNA-dependent RNA polymerases. 11. Mechanism of the inhibition of RNA polymerases B by amatoxins". Biochim Biophys Acta. 353 (2): 160–184. PMID 4601749.
