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| Names | |
|---|---|
| IUPAC name
2-Aminopent-4-enoic acid
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| Identifiers | |
3D model (JSmol)
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| ChemSpider | |
| ECHA InfoCard | 100.028.809 |
PubChem CID
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CompTox Dashboard (EPA)
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| Properties | |
| C5H9NO2 | |
| Molar mass | 115.13 g/mol |
| Appearance | white crystalline powder |
| Density | 1.098 g/mL |
| Melting point | 265 °C (509 °F; 538 K) |
| Boiling point | 231 °C (448 °F; 504 K) |
| Hazards | |
| Occupational safety and health (OHS/OSH): | |
Main hazards
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Irritant |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Allylglycine is a glycine derivative. It is an inhibitor of glutamate decarboxylase.[1] Inhibition of glutamate decarboxylase blocks GABA biosynthesis, leading to lower levels of the neurotransmitter.[2] Allylglycine is known to induce seizures in animals studies, presumably due to this GDC-inhibiting activity.[3]
References
- ^ Abshire VM, Hankins KD, Roehr KE, DiMicco JA (November 1988). "Injection of L-allylglycine into the posterior hypothalamus in rats causes decreases in local GABA which correlate with increases in heart rate". Neuropharmacology. 27 (11): 1171–7. doi:10.1016/0028-3908(88)90013-5. PMID 3205383.
- ^ Sajdyk T, Johnson P, Fitz S, Shekhar A (August 2008). "Chronic inhibition of GABA synthesis in the bed nucleus of the stria terminalis elicits anxiety-like behavior". J. Psychopharmacol. (Oxford). 22 (6): 633–41. doi:10.1177/0269881107082902. PMC 3065212. PMID 18308797.
- ^ Thomas J, Yang YC (June 1991). "Allylglycine induced seizures in male and female rats". Physiol Behav. 49 (6): 1181–3. PMID 1654571.